23 results
To demonstrate superiority of selepressin plus standard care versus placebo plus standard care in the number of vasopressor- and mechanical ventilator-free days (with penalty for mortality) in patients with vasopressor-dependent septic shock
Goal of our study is to compare the CO measuments by the Oesophageal Doppler Monitor (ODM, Cardio Q) with the TPTD technique (PiCCO) and to determine reliability of the ODM in absolute CO values and as a trend monitor. A validation study comparing…
Investigate the incidence and severity of early coagulopathy in severe sepsis and septic shock patients and investigate the correlation between these coagulation disturbances and the incidence and severity of microvascular changes.
To study dose-dependent hemodynamic and microcirculatory changes during oxygen supply in mechanically ventilated ICU patients.
To detect incipient central hypovolemia preceding symptomatic cerebral hypoperfusion by machine learning models trained on realistic physiological models.
The primary goal of this study is to determine if the use of multi-site NIRS-monitoring in newborn infants at risk of circulatory failure could lead to a better diagnosis, treatment and outcome in these infants compared to the use of conventional…
Primary objective: The primary objective of the study is to determine the effect of oral dipyridamole treatment on the innate immune response induced by a lipopolysaccharide (LPS) challenge. Various pro- and anti-inflammatory cytokines will be…
STUDY OBJECTIVESPrimary objectiveTo assess the safety, tolerability and local tolerance of two different intravenous infusion doses over 72 hours of a new dosing regimen and a new formulation of MCI-186 in subjects with acute ischemic stroke.…
Primary Objective: Our primary objective is to study the influence of two routinely used drugs to increase systemic blood pressure (phenylephrine and ephedrine) on cerebral oxygenation and perfusion, estimated by changes in cerebral oxygenation (…
To assess the effectiveness of an additional cardiovascular assessment and intervention to a multidisciplinary falls-intervention.
The primary objective of the study is to determine concentration of circulation cytokines na administration of LPS in the presence of iron sucrose (Venofer®), Deferasirox (Exjade®) of placebo.
The primary objective of the study is to determine the effect of atazanavir-induced hyperbilirubinemia on systemic activation of the innate immune response induced by human endotoxemia.Secondary objectives are:- To determine if the vascular…
The aim of the present study is to investigate cerebral vasoreactivity in response to lower body negative pressure in young and elderly healthy men, as a measure of cerebral autoregulatory responsiveness.
To investigate if norepinephrine is safe and effective in increasing blood pressure and systemic blood flow in premature and full-term neonates with shock and/or hypotension.
The main objective of the study is to determine the diagnostic and prognostic added value of careful history taking and Nexfin in the initial evaluation of (pre-) syncope patients in the ED and the follow-up period. The secondary objective is to…
To compare the accuracy of the above-mentioned methods in patients admitted to the ward or intensive care unit in estimating CVP and to investigate the correlation between the different methods.
In this study, we aim to investigate the postoperative time course of microcirculatory parameters in patients admitted to the ICU after cardiothoracic surgery with and without circulatory shock. Secondary objectives:* To study the postoperative time…
To determine the effect of SaO2 and PaO2 levels on mitoPO2 and markers of oxygen delivery and consumption in healthy human volunteers.
The primary aim of the study is to determine the incidence of perioperative hypovolemia in the elderly patient scheduled for major surgery, and how this relates to postoperative complications.
In this explorative-study, we aim to investigate the relation between cDPP3 release kinetics and clinical outcome parameters in OHCA patients after ICU admission. This could lead to the identification of a new predictive marker, a potential…