Search for a trial

Arterial stiffness, Blood Pressure and Cardiac output study; ABC-study;A Prospective, Multidisciplinary study of arterial stiffness measures in patients treated for aortic aneurysms in relation to blood pressure and cardiac output

Zie document PROTOCOL SYNOPSIS ABC study

Prevalence of vulnerable plaque in type 2 Diabetes Mellitus and its predictive value for future ischemic strokes

Primary:2. To investigate the prevalence of vulnerable plaques, i.e. plaques with intraplaque hemorrhage on MRI, in individuals with type 2 diabetes, impaired and normal glucose tolerance and a minimal plaque thickness of 2mm on ultrasonography. To…

The effect of resveratrol on metabolism and cardiovascular risk profile in patients with chronic obstructive pulmonary disease (COPD)

The overall objective is to investigate the efficacy of resveratrol in modulating metabolism and CVD risk profile in patients with COPD. The primary objective is to investigate the effect of resveratrol on CRP as clinical marker of low grade…

Anaerobic threshold in patients with pectus excavatum

The objective of this study is to demonstrate the influence of pectus excavatum on the anaerobic threshold during exercise. This could be an objective measurement of exercise intolerance. An objective measurement of exercise intolerance can later…

HeartMate PHP Cardiogenic Shock Pilot Trial

The primary objective of this study is to assess reasonable safety and performance of the HeartMate PHP to provide hemodynamic support for up to 72 hours in patients with cardiogenic shock requiring stabilization.

Activity and heartrate monitor validation study

The primary objective of this study is to determine the accuracy of energy expenditure and resting heart rate measurement.Secondary objectives include assessment of accuracy of other measures like sleep duration, steps counting, activity recognition…

Implication of MEDIcal low dose RADiation exposure _ EARLY detection of cardiovascular (HEART) changes after radiotherapy for breast cancer (MEDIRAD-EARLY HEART)

Primary objective: to identify the most important cardiac imaging (ECHO-ST, CT and MRI) and circulating biomarkers of radiation-induced cardiovascular changes arising in the first 2 years after BC RT and to develop Normal Tissue Complication…

ChanGes In Right ventricular volumes And Function Following diurEtic Treatment In Pulmonary arterial hypertension patients with decompensated right heart failure (GIRAFFE)

The primary objective of the study is to evaluate the effect of diuretics on right ventricular function and volume properties in patients with symptomatic right heart failure and PH.

A placebo-controlled, double-blind, randomized trial to evaluate the effect of 300 mg of inclisiran sodium given as subcutaneous injections in subjects with Atherosclerotic cardiovascular disease (ASCVD) or ASCVD- risk equivalents and elevated low density lipoprotein cholesterol (LDL-C)

The primary objective of this study is to evaluate the effect of inclisiran treatment on:•LDL-C levels at Day 510•Time adjusted percent change in LDL-C levels from baseline between Day 90 and Day 540 levels. The secondary objectives of this study…

Investigating cardiovascular adverse events related to cancer treatment: a study of extreme toxicity using induced pluripotent stem cells

To identify the pathophysiology and predictors of study (extreme) cancer treatment -induced cardiovascular toxicity in cancer patients, by in vitro investigation of cardiovascular toxicity in patient-derived cardiomyocytes (iPSC-CMs) and endothelial…

Detection of (sub) clinical toxicity in irradiated vs. non-irradiated surgically treated esophageal cancer patients: a pilot study.

The main objective of this study is to determine the most suitable diagnostic test to identify cardiopulmonary (dys)function in EC survivors treated with neo-CRT followed by surgical resection. Furthermore, we want to estimate the difference in…

A placebo-controlled, double-blind, randomized trial to evaluate the effect of 300 mg of inclisiran sodium given as subcutaneous injections in subjects with Atherosclerotic cardiovascular disease (ASCVD) or ASCVD- risk equivalents and elevated low density lipoprotein cholesterol (LDL-C)

The primary objective of this study is to evaluate the effect of inclisiran treatment on:*LDL-C levels at Day 510*Time adjusted percent change in LDL-C levels from baseline between Day 90 and Day 540 levelsThe secondary objectives of this study are…

Pharmacokinetic study to assess the bioavailability of phenolics from an olive leaf extract

The objective of the study is to obtain information on the bioavailability and pharmacokinetics of the phenolics present in an olive leaf extract (Bonolive®, dose 250 mg), standardized on 40% oleuropein, and to identify the composition of the…

Hemodialysis-induced fall in myocardial perfusion: identification of dialysis-specific triggers

To identify which component of hemodialysis is primarily involved in the reduction in myocardial blood flow.

Impact of prolonged exercise on cardiovascular function in healthy older humans: a pilot study

To examine the impact of prolonged (walking) exercise on cardiac and vascular function in older humans

Client IMplementation PatientCoach (CIMP)

The purpose of the study is to evaluate the usability of PatientCoach by patients with asthma and/ or COPD,hypertension and/or Diabetes Mellitus.

Rapid Renal Sympathetic Denervation for Resistant Hypertension Using the OneShot* Ablation System.

The OneShotTM System procedure is designed to provide the anatomical and physiologic benefits of catheter-based RDN at lesser risk to the subject, due to a reduction of complexity of the procedure and design improvements intended to enhance…

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Effects of Ranolazine on Major Adverse Cardiovascular Events in Subjects with a History of Chronic Angina Who Undergo Percutaneous Coronary Intervention with Incomplete Revascularization

The primary objective of this study is to:• Evaluate the efficacy of ranolazine as compared with placebowhen used as part of standard medical therapy in chronicangina subjects with incomplete revascularization post percutaneous coronary intervention…

Cardiovascular function after Stem cell Transplantation

To study whether CMR analysisdifferences in aortic stiffness and myocardial lipid accumulation between SCT recipients and healthy, age-matched controls

Exercise-related predictors of cardiac resynchronization therapy

The primary objective of the study is to establish the predictive value of the combination of cardiac and extra-cardiac exercise parameters with respect to the response to CRT in CHF patients. Secondary objective is to improve insight in exercise-…