62 results
To examine the effect of BCG vaccination on the composition and function of the bone marrow.
To evaluate whether neuromuscular ultrasound discriminates between patients with and without ICU-AW.To detect differences between patients that do and do not have ICU-AW in order to determine relevant cut-offs which can be used in future diagnostic…
To evaluate the role of white blood cell (WBC) scintigraphy in monitoring the response of infection treatment of a prosthetic joint infection.
To describe the wound related complication rate in post-bariatric body contouring surgery patients who are treated according to a new guideline and assess the factors associated with a higher complication rate.
The primary objective of this study is to monitor changes in oral health during a 3.5-month naval mission and once one month thereafter.
The primary objective of the study is to assess the function and effect of deiodinase type 3 in PMN*s and the mechanisms behind its induction following activation of these cells.
A previous study of from our laboratory showed that administration of the drug C1-INH (100E/kg) significantly reduced the concentration of circulating pro-inflammatory cytokines, such as IL-6, in healthy male volunteers during human experimental…
Predicting fluid responsiveness during PLR and fluid challenge (FC) by changes in (Pms).
1) To determine whether vaccination with yellow fever results in a higher cytokine response upon restimulation in vitro with non-related infectious pathogens, compared to the response before the vaccination.2) To determine whether BCG vaccination…
Primary objective: To determine if a single administration of SRT2379, at multiple dose levels, attenuates the inflammatory response in normal healthy male subjects after exposure to low-dose endotoxin (LPS)Secondary objectives: (1) To determine…
To develop a screening test to predict ICU-AW at an early stage in patients admitted to the ICU. Also by prospectively following the patient group in time, this study aims to describe the natural history and functional limitations in patients…
Primary objective: To determine if a single dose of SRT2379 attenuates the inflammatory response in normal healthy male subjects after exposure to low-dose endotoxin (LPS) Secondary objectives: (1) To determine PK of SRT2379 in normal healthy male…
to investigate if small nerve fibres are affected in patients with ICU-AW
Primary Objective•To assess the pharmacodynamic response after single dose administration of NOX H94 in healthy subjects during experimental endotoxemia.Secondary Objective• To determine the pharmacodynamic effects of NOX H94 after single dose…
1. Creating a reproducible and valid method for adenosine measurement2. Studying the effect of dipyridamole on the endogenous adenosine concentration before and after CPT.
In this study we aim to develop a predictive model for septic ICU*patients enabling the clinician to make a customized risk stratification and asses the patient*s immune status.
In this study we aim to study the dynamics of biomarkers and to develop a predictive model for septic ICU-patients enabling the clinician to make a customized risk stratification and asses the patient*s immune status.
1: Elucidation of the factors that cause the complement deficiency in pediatric oncology patients. First, we will characterize the inhibitor of MASP-2 activity in patients during chemotherapy. 2: Identification of the complement component(s) causing…
The primary aim of this pilot-study is to assess safety and the effects on immune function in patients with septic shock of adjunctive therapy with IFN-gamma, in a placebo-controlled manner. The data obtained will allow us to do a powercalculation…
The primary objective of the study is to determine the effects of hyperoxia and hypoxia in healthy volunteers on kinetics of HIF1α mRNA in circulating leukocytes. Secondary objectives are to determine the effects of hyperoxia and hypoxia on HIF1α…