29 results
To investigate whether peak melatonin level and daily secretion patterns differ between delirious and non-delirious older persons admitted to the ICU. To determine factors that potentially influence the association between delirium and melatonin…
To determine the safety and efficacy of transdermal nicotine replacement therapy in mechanically ventilated and active smoking patients admitted to the intensive care unit.
Primary objective(s):To evaluate the effect of early haloperidol prophylaxis on the incidence, severity and duration of in-hospital delirium in at-risk patients aged 70 years and over who are acutely admitted to the hospital through the ED, for…
To assess the potential of a short neuropsychological test measuring attentional variability and vigilance preoperatively in predicting postoperative delirium among elderly non-dementia patients undergoing elective surgery.
The primary outcome of this study is to assess whether the maximum ICDSC score achieved each day is related to PK parameters of haloperidol in ICU patients with delirium. Secondary outcomes: - To characterize the association between daily…
To investigate whether the Actiwatch® actigraph and the Everon* sensor can be helpful in the early diagnosis of a delirium. If both are able to do so, we evaluate which of the two performs best as a delirium screening device.
To evaluate whether preventive treament with haloperidol lowers the risk for delirium in stroke patients with an increased risk for delirium.
Objective: In this pilot study experience will be obtained in the simultaneous use of PSG, melatonin assay, CBT-measurement and assessment in ICU patients.
Primary Objective:In this pilot study, the authors aim is to investigate whether esketamine reduces the incidence of POD in elderly patientspresenting for noncardiac surgery.Secondary Objective(s):To examine whether esketamine has an effect on the…
To examine how sensitive certain (combinations of) EEG parameters are for diagnosing delirium in a heterogeneous group of ICU patients during 24 hours of EEG registration. The delirium assessment by delirium experts will determine which patients…
To study whether rivastigmine added to treatment with haloperidol shortens the duration of delirium in ICU patients and reduces costs.
The primary objective of this study is to test both the CAM-ICU and the ICSDS, using the DSM-IV criteria for delirium as golden standard. A secundary objective is to assess the value of the impression of the ICU physican whether or not a patient is…
Our objective is to validate multiple diagnostic instruments, especially the pCAM-ICU. By comparing these instruments, we can develope an algoritm which can be used by nursing staff to diagnose the pediatric delirium as soon as possible so that…
To Evaluate the differences between teh length of delirium in the anti-psychotics+ melatonin group and the anti-psychotics + placebo group.
To assess whether profylactic treatment with 3 mg melatonin daily for 5 days in acutely admitted eldery with hip fractures reduces the incidence of the development of delirium.
Primary objective:Plasma levels of clonidine, in order to describe pharmacokinetic and pharmacodynamic properties of intravenous clonidine in critically ill ventilated ICU patients.Secondary objectives are: * to evaluate the effect of a 3-hr loading…
The research question fort his study is: *What are the personal experiences of older hospital patients who have suffered a delirium, their family members, and their handling nurses?*. The aim of the current study is to gather the personal…
To obtain a nonlinear mixed effects model (NONMEM) describing the population pharmacokinetics of haloperidol in the central (CSF) and peripheral compartment after oral and intravenous injection.
To assess the efficacy of haloperidol to resolve delirium in adult critically ill patients and thereby render the patient awake and non-delirious.
Primary Objective: Testing the efficacy of tDCS as a 7 day add-on prevention in patients electively admitted to the ICU after cardiothoracic surgery on top of usual clinical care by measuring the change in delirium symptoms.Secondary Objective(s):…