11 results
To investigate the association between genetic factors and Hb recovery after blood donation. If an association can be found, the added value of genetic factors in prediction models for Hb deferral will be assessed. Also, the association between iron…
(Primary) Determine whether measuring the expression level is a good functional test for confirming the genetic diagnosis in IRIDA by establishing the relation between the TMPRSS6 mRNA expression and the phenotype in IRIDA patients and their family…
The effectiveness an cost effectiveness of PPIs compared to standard phlebotomy therapy in the prevention of iron overload in patients with hereditary hemochromatosis.
Evaluate if ironabsorption is disturbed after a RYGB, which leads to a insufficient treatment of oral ironsuppletion. Analyse if failure of oral ironsuppletion is predictable at baseline (T=0) in the absorption test.
In the current proposal, we propose an in vitro study to explore the interaction of malaria infection, the parasitized erythrocyte, and monocyte iron metabolism. We aim to study the role of hepcidin and to explore a) the pathways involved in malaria…
The main goal of the study is the identification of the mechanism of obesity related insulin resistance. We will study the relation between the different cell types in visceral and subcutaneous fat tissue and its influence on adipokine proflie.…
Which combinations of mutations in the HFE and HJV and other genes involved in iron metabolism are associated to iron overload?
The current study is designed to validate the secondary reference material identified in the previous study, and to produce a larger batch of this new calibrator for harmonization of worldwide hepcidin assays the next 5 years. For that reason, our…
To study the effects of FCM on exercise tolerance, haematinic parameters, quality of life, cardiac function, muscle function, bone and mineral parameters, microbiota, the immune system, the incidence of infections, allograft failure and mortality in…
To quantify the effect of ID on skeletal oxidative metabolism in patients with chronic HF with either preserved (HFpEF) or reduced (HFrEF) left ventricular ejection fraction.
The primary objectives are: 1) to obtain in vivo pharmacokinetic data of 4*-PPT (the study product) measured in plasma of PKAN patients; 2) to obtain pharmacodynamic data of the biomarker COASY in circulating lymphocytes of PKAN patients, when 4*-…