15 results
We aim to validate MRS with a cholinergic challenge as method to investigate muscarinic M1 receptor functioning. To investigate the relationship between the response to a muscarinic receptor antagonist with biperiden phMRI and [123I]IDEX SPECT…
Primary:To establish the safety and tolerability of rivastigmine when given with concomitant glycopyrrolate at an accelerated dose escalation schedule up to 12 mg BID.To establish the safety and tolerability of rivastigmine when given with…
The main objective of the current study is to determine the short-term effects of a glucose drink and a sacharose drink on memory, attention and mood in elderly men women.
This proposal entails a proof-of-concept study into the neuropsychological effects of memantine augmentation in a random cross-over comparison to placebo, as add-on treatment to ongoing clozapine in severely mentally ill (SMI) patients with…
The current study aims to further our understanding of the relationship between baseline measures - such as impulsivity, working memory and social support - and the effects of enhancing dopamine (via methylphenidate administration) across a wide…
Examine how unexpected reward and unexpected punishment affect working memory, that is, the ability to maintain information across time, update task-relevant information and ignore task-irrelevant information.Determine the extent to which…
Primary:1. to investigate the serotonergic HPA-axis activation (cortisol, ACTH, prolactin) in patients with a major depressive episode, using a newly developed oral 5-HTP-challenge administered before the first ECT treatment.2. to investigate the…
Primary Objectives- To replicate AVP-induced inhibition of anterior cingulate cortex (ACC) activity and functional connectivity as measured by BOLD fMRI during a face matching task. - To assess the effect of RO5285119 in the modulation of AVP…
The main objective of the study is to investigate the muscarinic cholinergic system as a biological substrate for cognitive dysfunction in first episode psychosis patients, i.e. at onset of illness. We seek to assess whether deficits in M1…
The main objectives of the trial are* To develop innovative evidence*based, feasible, effective and sustainable nutritional strategies for the prevention of depression in EU citizens.* To establish the feasibility and effectiveness of nutritional…
To investigate effect of a single dose of MK-1167 on glutamate levels in the brain using MRS. Glutamate is a chemical that sends signals between nerve cells in the brain. To test the safety and tolerability of single oral doses of the trial drug, MK…
The primary objective is to investigate if the stress-induced dynamics across stress systems are impaired in patients with CT-related depression compared to non-CT-related depression and healthy controls. The secondary objective is to examine how…
A possible treatment approach is cognitive remediation training (CR), a training developed to target cognitive deficits with the ultimate aim to improve daily functioning. Participants engage in cognitive exercises, learn more about their own…
Primary objectivesPart 1To evaluate the single dose safety and tolerability of donepezil 10 mg when administered with placebo, glycopyrrolate or trospiumPart 2To evaluate the safety and tolerability of donepezil when given with concomitant placebo,…
We propose to investigate the effect of administering a broad-acting, potent immune suppressive agent early in the course of the disease as this may prevent neuronal damage caused by low-grade inflammatory processes in the brain. It is expected that…