53 results
We aim to validate MRS with a cholinergic challenge as method to investigate muscarinic M1 receptor functioning. To investigate the relationship between the response to a muscarinic receptor antagonist with biperiden phMRI and [123I]IDEX SPECT…
Our primary objective is to investigate the effects of methylphenidate on language comprehension and creativity, and to link these effects with the effects of methylphenidate on working memory. Our secondary objective is to establish the relation…
The primary objective of this confirmatory study is to confirm the acid neutralisation action of Gaviscon Double Action Liquid versus placebo liquid, within the stomach.
to develop a *two hit* in vivo autologous RBCs transfusion model in healthy male volunteers.
The primary objective of this study is to determine the antialbuminuric response of vitamin D analogue in addition to ACE-inhibitor and low-sodium diet, in renal patients.
The objective of this exploratory study is to investigate the acid neutralisation action of sodium alginate oral suspension versus placebo liquid, within the stomach and to assess suitability and robustness of the pH monitoring methodology.
Determining the effect of short term ProManna intake on physiological parameters, notably biomarkers of oxidative stress. This pilot study serves to investigate whether ProManna intake leads to any changes in baseline levels for oxidative stress…
To study the effectiveness of supplementing a standard hospital and 12-week home menu with protein-enriched Cater with Care products in reaching a protein intake of 1,2-1,5 g/kg/day and in improving functional status after hospital stay in elderly…
The primary objective of the study is to assess the effect of missed doses of atomoxetine and OROS methylphenidate in ADHD patients who are stable on pharmacotherapy based on the patient*s daily behavior as assessed by the Daily Parent Report of…
- To educate adolescents about clinical drug studies by involving them as project team members and participants in an experiment with negligible risk and minimal burden;- To investigate the effects of paracetamol on nociception in adolescents; - To…
To test the gastric emptying properties of a whisked drink.
The objectives of the study are to investigate the acute effects of a single consumption of tomato ketchup on ex-vivo elicited inflammation (release of the cytokines TNF-α, IL-8 and IL-10 upon LPS stimulation), chemotaxis of monocytes ex-vivo and on…
In this pilot study, the time course of the increase in blood plasma levels of uridine after single intake of UMP and UMP-enriched products will be explored in healthy volunteers. Five intervention groups will be studied; three intervention groups…
This proposal entails a proof-of-concept study into the neuropsychological effects of memantine augmentation in a random cross-over comparison to placebo, as add-on treatment to ongoing clozapine in severely mentally ill (SMI) patients with…
to develop a *two hit* in vivo autologous RBCs transfusion model in healthy male volunteers.
To estimate the treatment effect as measured by progression free survival(PFS) of subjects receiving AMG 386 (at 2 doses) in combination with paclitaxel + bevacizumabrelative to paclitaxel + bevacizumab + placebo.
To investigate the effect of various dose regimens of Cyclogest® on secretory transformation of the endometrium in comparison to Crinone® and placeboTo investigate single and multiple dose pharmacokinetics of Cyclogest®To investigate safety and…
Primary objectives:The primary aims of this study are to explore the relation of the extent of VS dopamine release and amphetamine-induced behavioral responses and to characterize the PD effect of repeat-dose amphetamine in healthy subjects.…
The aim of this study is to investigate the effect of a single bout of NMES on muscle protein synthesis rates in healthy elderly males.
We want to investigate what the short term effect of fibres out of CRP is on energy intake, feelings of satiety, gastric emptying rate and blood glucose levels. Furthermore we want to see whether this effect differs between product types (dry vs.…