433 results
1-2 intramuscular injections with 100 mg dexamethason in persons without arthritis but with elevated serum levels of rheumatoid factor and or anti-CCP will lead to a reduction in antibody concentrations after 6 months and possibly to a lower…
Pre- and probiotics are able to change the composition of the altered intestinal microbiota that is found in allergic patients, indicating beneficial effects of these nutritional components in the prevention and treatment of allergic diseases. The…
To determine the cost-effectiveness of CBT compared to care as usual in patients with a recent onzet of schizophrenia, who suffer from persistent and recurrent symptoms of psychosis.
Explore the efficacy, safety and tolerability of oral R129160, 60 mg o.d. in patients with chronic idiopathic urticaria
Subjects in the PCD-04 arm will show less anthracyclin-induced cardiotoxicty then subjects in the placebo arm.
In the pathogenesis of medullary thyroid carcinoma a mutation of the RET thyrosine kinase system plays an essential role. In animal models the thyrosine kinase inhibitor imatinib showed tumor regression. So a Phase-2 study in patients with…
The primary objective is to investigate the effectiveness of a personalized 2-year multidomain lifestyle intervention on cognitive performance in older adults at risk of cognitive decline.
1. TGF-beta protects childhood cancer patients against chemotherapoy induced damage in the digestive tract; 2. TGF-beta can safely be administered to childhood cancer patients.
We expect better outcomes: ABC > CBM > sham-CBM
rTMS has a positive effect in the treatment of depression.
Long-chain triglyceride (LCT) emulsions with di-unsaturated fatty acids will lead to enhanced postprandial satiety and reduced energy intake in a subsequent meal, as compared to LCT emulsions with mono-unsaturated or saturated fatty acids.
The hypothesis is that MS is a T cell-mediated autoimmune demyelinating disease of the central nervous system (CNS). In order to start immune reactions in the CNS, myelin antigen need to be presented on the surface of antigen presenting cells (APCs…
Asthma reduction at age 6 is possible with inhaled corticosteroids in children of 1-4.5 years old with a familial predisposition for asthma in the first degree, who develop wheeze symptoms.
Compliance with patching therapy for amblyopia can be improved by an educational programme aimed primarily at the child.
1. We hypothesize that the ingestion of 30 g of collagen peptides and 30 g of free amino acids (matching the profile of collagen peptides) will result in greater myofibrillar and connective tissue protein synthesis rates in skeletal muscle tissue at…
Antioxidants or anticytokines may suppress the autoimmune reaction in orbital tissues in Graves' orbitopathy patients. Nul hypothesis: selenium and pentoxifilline are as effective as placebo in mild Graves' orbitopathy.
The primary objective of this study is to determine whether treatment with statins reduce the progression of aortic stenosis in young adult patients with congenital aortic stenosis.
We hypothesize that restoration of gut microbiota diversity (by using donor FMT enriched in Desulfovibrio strains) could have explicit beneficial effects on glucose metabolism and NAFLD (via improved fructose catabolism), which is driven by…
Higher doses of statins will result in additional improvement of the diabetic lipid profile.
We hypothesize that methylphenidate improves ADHD manifestations in adults with (late-diagnosed) PKU.