19 results
To assess the efficacy, measured as progression free survival, and safety of Selumetinib in combination with docetaxel, compared to docetaxel alone, in patients receiving second line treatment for KRAS mutation negative locally advanced or…
The primary goal of this study is to investigate the effect of low doses of mirtazapine and quetiapine on sleep, assessed using polysomnography and subjective sleep measures, of healthy subjects whose sleep will be disturbed by auditory stimuli (…
investigate the value of percutaneous pulsed radiofrequency, applied to the lumbar and sacral dorsal root ganglion; more specifically try to determine if a significant and long lasting pain reduction can be obtained as compared to a sham-operated…
To test the hypothesis that The Transporters will show significant more improvement in contextual understanding of emotions and social functioning in children with ASD and BIF than a control intervention.
Primary objectiveThe primary objective of this trial is to compare TauroSept® (taurolidine 2% solution) with saline solution 0.9% as catheter lock solutions to prevent catheter-related bloodstream infections (CRBSI) in patients on home parenteral…
The primary objective of this study is to investigate the effect of a meal-like amount of dietary protein prior to sleep on postprandial muscle protein synthesis in healthy young and elderly men, following exercise, during the night. Furthermore, as…
STUDY 1: To investigate the impact of prior ingestion of a single high protein meal on the normal obligatory increase of muscle protein synthesis rates after protein intake and physical activity in healthy young men. STUDY 2: To investigate the…
The primary objective of this double blind study is to determine the effects of 1 mg, 4 mg, or 8 mg of ARA 290 administered subcutaneously for 28 consecutive days versus placebo on corneal nerve fiber density
Profylactisch 200ugr salbutamol kan tot 50% beschermen tegen de inspiratoire luchtwegobstructie gemeten in MIF50 die bij de meerderheid van de astmatische kinderen met FEV1 daling tijdens/na inspanning optreedt.
Liraglutide is an effective and safe treatment modality in metformin-treated patients suffering from schizophrenia with anti-psychotic drugs-related diabetes mellitus.
It is hypothesized that respiratory depression from the opioid oxycodone will increase with concomitant administration of alcohol. Furthermore it is hypothesized that the increase in respiratory depression is not only dependent on the dosage of…
Insomnia patients form a heterogeneous group, each phenotypes of insomnia will show different therapeutic demands.
The hypothesis to be tested is that the outcome in arm B is better than in arm A.
Stepwise selection of patients with cholecystolithiasis for cholecystectomy is not inferior to usual care with respect to the patient reported outcome, but attributes to a more appropriate use of care and provides a basis for a lower number of…
1. Treatment resistant depression (TRD) is characterized by dopaminergic dysfunction as assessed with a fMRI Pavlovian learning task and [11C]Raclopride PET with amphetamine challenge; 2. Relative to placebo, current serotonergic and noradrenergic…
1. Repetitive Transcranial Magnetic Stimulation (rTMS), Transcranial Direct-Current Stimulation (tDCS) and Behavioural Activation Therapy (BAT) following rTMS will reduce feelings of apathy, increase goal directed behaviour and might be beneficial…
Primary: are there differences between the online course group and the control group in the change in depressive complaints from baseline to follow-up measurements? Secundary: Is the intervention cost-effective compared to a no preventive…
An online intervention will be an effective intervention for treating affective symptoms in pregnancy and their complications by reaching more women and making therapy easier accessible
ARA 290 improves neuropathic symptoms in patients with type 2 diabetes.