25 results
Primary Objective:The primary objective of this study is to determine whether treatment with JNJ-54861911 slows cognitive decline compared with placebo treatment, as measured by a composite cognitive measure, the Preclinical Alzheimer Cognitive…
The primary objective is to determine the effects of dietary nitrate (beet root juice) on the microcirculatory profile in healthy adults. The secondary objectives are 1) to determine the effects of dietary nitrate on macrocirculatory parameters, 2)…
We hypothesize that stepwise dose of intravenous infusion of nitroglycerin reverses clinical abnormalities of peripheral circulation in patients with circulatory shock and that this can lead to improvement in survival rate. In addition, we expect…
To evaluate the efficacy of VX-661 in combination with ivacaftor and ivacaftormonotherapy through 8 weeks of treatment in subjects with cystic fibrosis (CF)who are heterozygous for the F508del mutation on the CF transmembraneconductance regulator (…
Primary objective is to examine the effect of tryptophan supplementation on the number of accepted unfair offers in the Ultimatum Game. Secondary objectives are to examine the effect of tryptophan supplementation on the response bias in a social…
Primary Objective: To determine the effect of omega-3 PUFAs on exercise performance. Secondary Objective: To determine the effect of omega-3 polyunsaturated fatty acids supplementation on performance determining variables, such as VO2max, VO2 at the…
To evaluate the efficacy of VX-661 in combination with ivacaftor through 24 weeks of treatment in subjects with cystic fibrosis (CF) who are homozygous for the F508del mutation on the CF transmembrane conductance regulator (CFTR) gene.
To determine whether computerized training procedures can lead to a decrease of aggression-related attention andinterpretation, and whether this reduces aggressive behaviors.
We hypothesize that iABM patients, relative to controls, will show less addiction problems, increased health, reduced physical and psychological complaints, and reduced use of health care post-intervention and at 6 & 12 month FU Further, we…
-Children who receive the more prolonged working memory training with personalized coaching have less behavioural problems (VISK, AVL, BRIEF) after the training compared to children who receive the more prolonged working memory training without…
Anti-nociception is an existing or attainable state of pain modulation that can be reached by specific pharmacological agents coupled to individual patterns of pain modulation. Being in, or shifted into anti-nociception state of pain modulation,…
The central hypothesis of our study is that routine postsurgical anesthesia visits reduces postoperative 30-day mortality by 30%.
Single dose intranasal dexmedetomidine can be administered safely to elderly people as premedication with respects to hemodynamic changes, irrespective of the concurrent use of betablocking medication
the active treatment group has an improvement of at least 10 points of DASH functional outcome more than the placebo group.
Improving functional outcomes in rectal cancer surgery by a pelvic floor rehabilitation program.
Breast cancer patients with chronic pain at the breast region will have a greater decrease in pain after a botulinum toxin infiltration, an individual physical therapy programme and home exercise programme than patients who reveive a saline solution…
It is hypothesized that an intervention with the KPR could decrease pelvic tilt, as measured using clinical leg length difference and the ASIS-PSIS angle, for 50% or create a crest height difference smaller than 0.5 centimeters in patients with non…
We perform this randomized trial to test the hypothesis that a combination of paracervical anesthesia and fundal anesthesia is not superior to paracervical anesthesia only.
Protein supplementation will augment the training induced gains in skeletal muscle mass and strength.
Bezafibrate will significantly reduce post-prandial non-HDL cholesterol in patients with Familial Dysbetalipoproteinemia compared to placebo.