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LSD microdosing

The present study explores the dose-response relationship in LSD-induced subjective and cognitive effects using small doses of LSD (5, 10, and 20 µg) compared to placebo. The study hypothesis is that higher doses of LSD will be associated with…

Amitriptyline en mirtazapine bij langdurige slapeloosheid

Compared to placebo treatment with low dose amitriptyline or mirtazapine during 16 weeks will improve subjective insomnia in insomnia disorder patients in general practice.

Het effect van probiotica op vitamine K status

We hypothesize that probiotics with vitamin K2 producing properties can improve vitamin K status.

Treatment With Leflunomide in Patients With Polymyalgia Rheumatica

Leflunomide is able to reduce the relapses, the glucocorticoid use and the adverse events associated with glucocorticoid s use in PMR patients.

Ketamine Trial Amsterdam (KETA), pilot

A single subanesthetic dose of intranasal ketamine is able to diminisch acute suicidal ideation and behaviour, regardless of the underlying diagnosis.

Study on the efficacy of rituximab in patients with polymyalgia rheumatica

RTX 1*1000 mg compared to a placebo controlled group leads to a higher proportion of patients in glucocorticoid remission at week 21 in newly diagnosed PMR patients fulfilling the Chuang-criteria

Biperiden challenge study

Biperiden deteriorate the cognition that biperiden will be used for a challenge model.

A clinical trial to investigate immunotherapy (IMO-2125) in the skin of patients with a melanoma which is at least 2 millimeters thick

Intradermal IMO-2125 treatment can result in a loco-regional anti-tumor immune response and SLN tumor clearance and a longer recurrence-free and overall survival in patients with cT3-4N0M0 melanoma.

Pharmacological effects on nerve excitability in healthy volunteers

In this study we will validate nerve excitability threshold tracking, a measurement technique for neuronal excitability. The placebo-controlled mexiletine and lacosamide administration should inform us about the sensitivity of threshold tracking to…

Preventie van infecties na open chirurgische ingrepen

We hypothesize that induction of trained immunity through BCG vaccination may improve host defence mechanisms of patients throughout the perioperative period.

The difference between Bright Light Therapy and Biodynamic Lighting for patiënts with moderate-to-severe dementia: a double-blind, randomized, placebo-controlled trial.

the present study investigates whether Circadian adjusted LED-based (biodynamic) lighting improve cognitive functions, circadian rhytm, behavioral problems (apathy and agitation), Quality of life and mood (depression) in patiënts with moderate- to…

The effect of Transcranial Direct Current Stimulation (tDCS)
as an intervention to reduce violent behavior in forensic substance abuse patients.

The aim of this study is to investigate the effectiveness of tDCS in increasing empathy and reducing violent behavior in offenders with substance abuse problems.Through stimulation (and/or inhibiting) certain areas of the brain, tDCS causes a change…

Enhancing Motor Learning with a Single Dose of Levodopa

To identify the role of dopamine transmission in the GC layer on motor learning in healthy individuals during cerebellar specific motor adaptation tasks.

Effect of dietary therapy with a probiotic mixture (Ecologic BARRIER) on the gut microbiome and fatigue symptoms in patients with quiescent inflammatory bowel disease - A clinical trial

To evaluate the effect of dietary therapy with a probiotic supplement on the composition of stool microbiome in fatigued IBD patients with quiescent diseaseTo define the effect of dietary therapy with a probiotic supplement on serum inflammatory…

The protective effect of Masquelier*s® French Pine Bark Extract with Original OPC in half-marathon runners using a single low dose of ibuprofen

In the present study we aim to assess the efficacy of a 14-days intervention with monomeric and oligomeric flavanols from Vitis vinifera seeds and Pinus pinaster bark (MOF-VVPB) which are the active principle in Masquelier*s® French Pine Bark…

Single dose escalation study in a single center, randomized, single blind, placebo controlled, group comparison design to investigate pharmacokinetics, safety and tolerability of BAY 2253651 after intravenous administration in healthy male subjects.

The main purpose of this study is to investigate how quickly and to what extent BAY 2253651 is absorbed (taken up), distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). Multiple dose steps of BAY…

Interventions with Music in Pectus Excavatum Treatment

This research will investigate a non-pharmacological, low-cost, durable and safe method during and after pectus excavatum surgery, to alleviate postoperative pain and thereby reduce the dose of analgesics used. Our secondary aim is to investigate…

A phase 3, randomized, double-blind study comparing risankizumab to placebo in subjects with active psoriatic arthritis including those who have a history of inadequate response or intolerance to biologic therapy(ies).

The primary objective of the study is to compare the efficacy of risankizumab versus placebo for the treatment of signs and symptoms of PsA in subjects who have a history of inadequate response to or intolerance to at least one biologic therapy.

Can Acetaminophen Ease the Heartbreak of Social Rejection?

Primary objective is to examine the effect of acetaminophen on the cardiac deceleration associated with the painful experience of social rejection.

The effect of intravenous lidocaine to prevent intracranial pressure increase in endotracheal intubation assessed by optic nerve sheath diameter

Primary Objective: To investigate the effect on the distention of the ONSD while using lidocaine 1,5 mg/kg IV during endotracheal intubation versus placebo. Secondary Objectives: The secondary objective of this study is to investigate the effect…