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THE EFFECT OF NIACINAMIDE SUPPLEMENTATION ON PHOSPHATE CONCENTATIONS IN DIALYSIS PATIENTS.

The main study parameter is the routine measurement of serum phosphate concentrations after 8 and 12 weeks. Other study parameters are compliance to phosphate binders and supplement-related complaints such as nausea, diarrhoea, flushing and itchness…

A Double-Blind, Randomised, Placebo-Controlled, Multi-Centre Field Study to
Assess the Efficacy and Safety of HDM-SPIRE in Subjects with a History of House
Dust Mite-Induced Rhinoconjunctivitis

To evaluate the efficacy of HDM-SPIRE in the reduction of symptoms and the use of allergy rescue medication associated with HDM allergy in subjects with clinically relevant symptoms.

Effects of Tryptophan Supplementation on Feedback Processing in Healthy Volunteers

Primary objective is to examine the effect of tryptophan supplementation on the number of accepted unfair offers in the Ultimatum Game. Secondary objectives are to examine the effect of tryptophan supplementation on the response bias in a social…

The effect of supplementation with fish oil rich in omega-3 polyunsaturated fatty acids on exercise performance

Primary Objective: To determine the effect of omega-3 PUFAs on exercise performance. Secondary Objective: To determine the effect of omega-3 polyunsaturated fatty acids supplementation on performance determining variables, such as VO2max, VO2 at the…

Venlafaxine for prevention of oxaliplatin-induced peripheral neuropathy - A randomised clinical trial

Given the significant number of patients with OIPN and the possible prophylactic properties of venlafaxine, this study is designed. This study will consist of a randomised placebo-controlled clinical trial to study the prophylactic effect of…

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate
the Efficacy and Safety of VX-661 in Combination With Ivacaftor in Subjects Aged 12 Years and Older With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation

To evaluate the efficacy of VX-661 in combination with ivacaftor through 24 weeks of treatment in subjects with cystic fibrosis (CF) who are homozygous for the F508del mutation on the CF transmembrane conductance regulator (CFTR) gene.

A computertraining for positive attention and interpretations to reduce aggressive behaviors in childen with conduct problems.

To determine whether computerized training procedures can lead to a decrease of aggression-related attention andinterpretation, and whether this reduces aggressive behaviors.

A Three Arm Double blind, Randomised, Multicenter Study to investigate the Non-Inferiority of a Soft Gel Capsule of Ibuprofen Lipid Formulation (total daily dose 1200 mg) versus a standard Soft Gel Ibuprofen capsule (total daily dose 1200 mg and 2400 mg) in the Treatment of Patients with Episodic Knee Arthralgia/Flaring Knee Pain.

The principal aims of the study are to assess: 1. The effectiveness of a 5 day treatment course in arresting/ resolving episodic knee arthralgia/ flaring knee pain.2. The relative effectiveness of a low dose (1200 mg/day) of lipid formulated…

The longitudinal effects of repetitive tDCS on cigarette consumption: An ecological momentary assessment (EMA) study

The primary objective of the study is to explore the effect of repetitive tDCS (left cathodal/right anodal) on mean daily cigarette consumption three months after tDCS by means of ecological momentary assessments (EMAs).To examine the course of…

The effects of transcutaneous vagus nerve stimulation on perseverative cognitions in daily life.

The main objective of the current study is to assess whether tVNS affects perseverative cognition, especially worry, in the daily lives in chronic worriers.

The effects of repetitive tDCS on relapse in cocaine addiction: An ecological momentary assessment (EMA) study

The aim of this study is to explore the effectiveness of repetitive bilateral tDCS (left cathodal/right anodal) over the DLPFC on relapse in cocaine addicts. Craving, temptations and cognitive control functioning will be assessed as predictors of…

Sulodexide for chronic heart failure: a proof of concept, randomized, open-label, placebo-controlled study

To assess the efficacy of treatment with sulodexide for chronic heart failure.

Randomized controlled trial to assess the effect of vitamin K supplementation on the rate of elastin degradation in COPD

To evaluate whether supplementation of vitamin K2 decelerates the rate of mature cross-linked elastin degradation inpatients with COPD.

Complement Inhibition: Attacking Overshooting inflammation @fter Subarachnoid Hemorrhage (CIAO@SAH trial)

This study has been transitioned to CTIS with ID 2025-520540-15-00 check the CTIS register for the current data. Primary Objective: To determine the safety and efficacy of 6000 IU C1-INH in patients with subarachnoid hemorrhage (SAH)Primary…

Interventions with Music in Pectus Excavatum Treatment

This research will investigate a non-pharmacological, low-cost, durable and safe method during and after pectus excavatum surgery, to alleviate postoperative pain and thereby reduce the dose of analgesics used. Our secondary aim is to investigate…

A 2-Part, Randomized, Double-blind, Double-Dummy, Placebo- and Active Comparator-controlled, Repeat Dose Study to Establish Proof-of-Concept of GRX-917 in Experimentally Induced Panic and to Further Characterize its Repeated Dose Pharmacokinetics and Pharmacodynamics in Healthy Subjects

Part 1:Primary Objective- To investigate whether repeated dose GRX-917 reduces panic symptoms elicited by an experimental 35% CO2 -induced fear challenge administered in healthy CO2-sensitive subjects. Secondary Objectives- To investigate whether…

A randomized, placebo-controlled, double-blind, multi-center Phase 2/3 trial to assess efficacy and safety of octreotide subcutaneous depot (CAM2029) in patients with symptomatic polycystic liver disease

This study has been transitioned to CTIS with ID 2023-505313-24-00 check the CTIS register for the current data. To evaluate the treatment effect of CAM2029 compared to placebo on liver volume in patients with polycystic liver disease (PLD)

A visual-developmental perspective for children born very preterm

The main objective of this study is to investigate the effectiveness of early visual assessment and early rehabilitation of VPD in very preterm children (born <30 weeks GA), from 1 year CA.

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study
Evaluating the Safety and Efficacy of Selonsertib in Subjects with
Compensated Cirrhosis due to Nonalcoholic Steatohepatitis (NASH)

The primary objective of this study is:• To evaluate whether selonsertib (SEL, previously known as GS 4997) can cause fibrosis regression and reduce associated complications in subjects with cirrhosis due to NASH. The secondary objective of this…

Randomized, Double-Blind, Placebo-Controlled, Dose-Ranging, Efficacy and Safety Study with Inhaled RVT-1601 for the Treatment of Persistent Cough in Patients with Idiopathic Pulmonary Fibrosis (IPF): SCENIC Trial

To assess the efficacy of inhaled RVT-1601 in comparison with placebo following 12 weeks of treatment