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Cost-effectiveness of Early Surgery versus Conservative Treatment with Optional Delayed Meniscectomy in older Patients. A Randomized Controlled Trial.

The objective of this study is to evaluate the effectiveness and cost-effectiveness of surgical and conservative treatment of non-obstructive meniscal injuries in older patientsHypothesis: We assume equal improvement of physical function in both…

Clinical comparison of the straight lateral approach and the anterior approach to the hip.

The objective of this project is to 1. increase accuracy and reproducibility of the most critical step in hip arthroplasty i.e. cup positioning;2. to alleviate one of the major complications of the straight lateral approach, i.e. abductor…

Uncemented tibial component fixation in total knee replacement using porous titanium. A Randomized RSA Study

The aim of this study is to compare the early post-operative migration as measured by Roentgen Stereophotogrammetric Analysis (RSA) of the uncemented tibial component with plasma spray coating with the uncemented porous coated tibia component.

A prospective randomised Rontgen Stereophotogrammatic Analysis (RSA) study using the uncemented Trident Tritanium acetabular component and the uncemented HA coated Symax hip stem in a single centre.
Assessment of implant migration, bone remodeling and clinical function.

The goal of this clinical investigation is to assess the early migration and bone remodeling of the Symax hip stem and the Trident HA coated or Trident Tritanium acetabulum component with RSA and 18-F PET CT Also the sensitivity of the RSA…

A prospective randomized trial comparing the effect of two different methods of anesthesia for reduction of displaced distal radius fractures; haematoma block versus peripheral nerve block at the elbow

To compare the effect of two different methods of anesthesia on painsensation (VAS score) during fracture reduction.

Dorsal spondylodesis in adolescent idiopathic scoliosis: proximal fixation with screws versus claw construct

The main objective is to compare the coronal Cobb angle correction of proximal hook claw fixation versus proximal pedicle screw fixation after two years of follow-up. The secondary objectives of the study are: comparison of coronal Cobb angle…

Effect of local anesthetic dose versus volume on block duration of single shot ultrasound-guided axillary brachial plexus block with mepivacaine.

Primary objective: to determine the effect of mepivacaine dose and volume on the duration of sensory axillary brachial plexus block (overall and individual nerves).Our hypothesis (H0) is that there is no difference (less than 60 min) in duration of…

Pain management after operative treatment of extremity fractures, a randomized clinical trial

The primary objective of this study is to determine (differences in) patient satisfaction with pain relief and pain intensity (Numeric Rating Scale) using a step 1 vs. a step 2 based analgesic regimen.The secondary objective is to determine…

Optimizing the intermanual transfer effects after training with a prosthetic simulator

The objective of this study is to determine the optimal myo-electric prosthesis training for obtaining the largest transfer effect. Here fore we plan to execute three experiments. At first it needs to be revealed which trainingtasks leads to the…

Radiological evaluation of CT based vs MRI based Signature* for total knee arthroplasty

PrimaryTo evaluate the alignment of the Signature* CT-based procedure compared to the Signature* MRI-based instruments.SecondaryTo evaluate the efficacy of the CT-based Signature* procedure in terms of operation time compared to the Signature* MRI-…

Anterior cruciate ligament CT study:
Transtibial, anteromedial portal, tape locking screw reconstruction technique

The main objective of this study is to compare the femur tunnel positioning after AMP, TLS and TT reconstruction techniques. We will also look at the relation between tunnel positioning and tunnel widening.

Comparative roentgen stereophotogrammetry analysis (RSA) between the conventional Mallory- Head stem in primary uncemented total hip replacement compared to two shorter variations

Objective: To perform a comparative assessment between the clinical, bone remodelling, and radiographic outcomes (as measured with RSA) of the conventional Mallory-Head stem compared two shorter versions of Mallory-Head stems in patients undergoing…

Joint distraction (KJD) in treatment of knee osteoarthritis: cartilage changes in a comparison with a presently applied surgical alternative: high tibial osteotomy (HTO)

1. To compare cartilage changes after KJD and after HTO, based on MRI, radiographs and biomarkers, evaluated 2 years post treatment. 2. To compare clinical efficacy after KJD and after HTO during 2 year follow-up by a questionnaire (KOOS; for pain,…

Primary stability of cemented vs uncemented stems in revision total knee arthroplasty measured with RSA: a randomised controlled trial.

Which technique, cementing or press-fit implanting, of the tibial and femoral stem of the Legion revision total knee prosthesis provides the most primary stability?

Wear analysis of cross-linked versus standard polyethylene F.A.L. acetabular cups in patiënts with symptomatic coxarthrosis: a randomized controlled trial

Primary goal: mean linear wear of the cross-linked polyethylene F.A.L. cup compared to the mean linear wear of the standard polyethylene F.A.L. cup at 5 years postoperatively. Secondary goals:1. mean linear wear (millimeters/year) at 1 year, 3 years…

Trapeziectomy with LRTI or simple trapeziectomy for treating trapeziometacarpal osteoarthritis stage 4: a randomized clinical trial

To research if trapeziectomy with LRTI leads to better results than trapeziectomy on the long term, with subjective and objective outcome measures.

Patient Blinded Randomized Clinical Trial comparing two types of mobile bearing unicondylar knee replacement

To assess non inferiority of a Multi Radius design (ACS® unicondylar) compared to a Single Radius design Unicondylar knee implant (Oxford) on clinical outcome using the Oxford Knee Score.

A comparison of ultrasound-guided fascia iliaca compartment block versus parenteral opioids for analgesia in emergency department patients with hip fractures: a single centre randomised controlled study

The primary objective of this study is to compare the efficacy of ultrasound-guided fascia iliaca block (FICB) to standard treatment with parenteral opioids for pain control in patients with hip fractures in the emergency department. Is there a…

A Clinical Study to Evaluate the Safety and Effectiveness of NOVOCART® 3D plus Compared to Microfracture in the Treatment of Articular Cartilage Defects of the Knee

Primary ObjectiveTo demonstrate that the effectiveness of the NOVOCART® 3D plus autologouschondrocyte transplantation system is superior to microfracture for the treatment ofarticular cartilage defects of the knee by demonstrating superiority of the…

Long-term results of acromioplasty and bursectomy versus bursectomy alone in the treatment of subacromial impingement syndrome. Clinical and radiological outcome after 8-13 years.

The aim is to study the long-term functional and radiological results (i.e. cuff integrity) of arcromioplasty in patients with SIS after a 8-13 year follow-up period.