45 results
The objective of the present study is to investigate whether home-based exercise training with telemonitoring guidance results in improved long-term physical fitness and higher activity levels than regular centre-based exercise training in patients…
Within this project we aim to determine the energetic conditions that underlie the transition to hypertrophy of the HOCM heart. A prospective comparison will be made between results of PET, MRI and function of cardiac myofilaments (in vitro). Also,…
Primairy objectives:1.To investigate whether a non-invasive imaging guided strategy (either CTA or CMR) early in the diagnostic process reduces the number of patients with at least one ICA during the initial admission as compared to routine clinical…
The main objective of this study is to evaluate whether myocardial ischemia in the absence of obstructive CAD in athletes is associated with a reduced myocardial perfusion when compared to control subject with a low a priori risk of CAD and without…
Primary Objective: To assess the analytical performance of the cardiac reader Secondary Objective(s): To assess the user friendliness of the device (handling, analytical speed).
Primary ObjectiveThe primary objective of this study is to compare prospectively in patients treated with TCZ or etanercept (ETA), the time to first occurrence of any component of a composite of major adverse cardiovascular events (MACE) consisting…
The primary objective of this study is to assess the neointimal healing score (as evaluated by intra-coronary OFDI) in patients with STEMI and treated with Abbott Vascular ABSORB everolimus eluting bioresorbable vascular scaffold (BVS) at 6 months…
To examine the effect of remote ischemic preconditioning on exercise-induced cTn elevations and indices of cardiac function.
The feasibility of direct-detection of fibrotic tissue will be assessed in patients with a healed myocardial infarction and in patients with cardiomyopathy using LGE as reference standard.
To compare cerebral activity patterns during emotional and cognitive processing among patients with post-MI depression and patients with regular depression.
We hypothesised that cardiovascular changes already exist in children with cystic fibrosis compared with healthy control children. Therefore, we will evaluate the cardiovascular system in a group of children with cystic fibrosis compared with…
To assess cardiovascular structure and function, physical capacity and traditional CVD risk factors in i) physical active subject with MI and ii) physical active subjects without MI.
The primary objective of this study is to determine whether glucagon-mediated activation of the calcineurin-pathway is associated with LVH in severely insulin-resistant diabetic subjects.
To assess the suitability of the (HR)2 programme in the Dutch setting and compare the efficiency of the (HR)2 programme with traditional cardiac rehabilitation in the Netherlands.
The objective of this study is to evaluate the safety and efficacy of the MGuard* Prime stent in the treatment of de novo stenotic lesions in coronary arteries in patients undergoing primary PCI due to acute STEMI as compared with BMS or DES in the…
To study the effect of 80 mg aspirin intake at bedtime compared with 80 mg aspirin intake on awakening on circadian rhythm of platelet function in healthy subjects.
To investigate if infarct size can be limited by introduction of IABP prior to intervention.
To investigate whether exposure to nanoparticles is able to induce short-term functional changes in the brain, we previously exposed human volunteers for one hour to diesel exhaust particulates (300 ug/m3) and followed their brain activity during…
Analysis of the effects of the Twin-Pulse Life Support on on the systemic inflammatory response and the effect on microvascular blood flow in ocmparison to standard used Extracorporeal Circuit Device
Our first objective is obtaining hypertrophic myocardial tissue for identifying novel biomarker, indicative and predictive for the severity of cardiac hypertrophy. Our second objective is validation of biomarkers detected in previous studies.