45 results
The primary objective of this study is to assess the neointimal healing score (as evaluated by intra-coronary OFDI) in patients with STEMI and treated with Abbott Vascular ABSORB everolimus eluting bioresorbable vascular scaffold (BVS) at 6 months…
To evaluate safety of 3-months versus standard 12-months of DAPT
The aim of this *proof-of-principle* study is to demonstrate that 18F-florbetaben PET can detect amyloid deposition in the myocardium in patients with proven cardiac amyloidosis and excluded amyloid deposition in the myocardium of healthy subjects.…
The feasibility of direct-detection of fibrotic tissue will be assessed in patients with a healed myocardial infarction and in patients with cardiomyopathy using LGE as reference standard.
The study hypothesis is that anticoagulation with bivalirudin for primary PCI in STEMI subjects with a 4 h infusion post-PCI will reduce infarct size compared with anticoagulation with UFH as assessed by CMR 5 days after the index event.The primary…
The objective of the present study is to investigate whether home-based exercise training with telemonitoring guidance results in improved long-term physical fitness and higher activity levels than regular centre-based exercise training in patients…
To compare cerebral activity patterns during emotional and cognitive processing among patients with post-MI depression and patients with regular depression.
The primary objective of this study is to determine whether glucagon-mediated activation of the calcineurin-pathway is associated with LVH in severely insulin-resistant diabetic subjects.
To assess cardiovascular structure and function, physical capacity and traditional CVD risk factors in i) physical active subject with MI and ii) physical active subjects without MI.
To assess the suitability of the (HR)2 programme in the Dutch setting and compare the efficiency of the (HR)2 programme with traditional cardiac rehabilitation in the Netherlands.
We hypothesised that cardiovascular changes already exist in children with cystic fibrosis compared with healthy control children. Therefore, we will evaluate the cardiovascular system in a group of children with cystic fibrosis compared with…
Analysis of the effects of the Twin-Pulse Life Support on on the systemic inflammatory response and the effect on microvascular blood flow in ocmparison to standard used Extracorporeal Circuit Device
1. The primary aim of the study is to investigate whether periodontal treatment results in a decrease of plasma biomarkers that are related to cardiovascular diseases (CVD) and metabolic syndrome (MS) and what is the effect of the treatment on the…
To investigate whether exposure to nanoparticles is able to induce short-term functional changes in the brain, we previously exposed human volunteers for one hour to diesel exhaust particulates (300 ug/m3) and followed their brain activity during…
The aim of this project is to study SNPs in genes involved in the cholesterol lowering pathway and in the anti-inflammatory pathway of statins to explain differences in the protective effect of statins against myocardial infarction (MI). A second…
To study the effect of 80 mg aspirin intake at bedtime compared with 80 mg aspirin intake on awakening on circadian rhythm of platelet function in healthy subjects.
The objective of this study is to evaluate the safety and efficacy of the MGuard* Prime stent in the treatment of de novo stenotic lesions in coronary arteries in patients undergoing primary PCI due to acute STEMI as compared with BMS or DES in the…
To examine the effect of remote ischemic preconditioning on exercise-induced cTn elevations and indices of cardiac function.
Primary ObjectiveThe primary objective of this study is to compare prospectively in patients treated with TCZ or etanercept (ETA), the time to first occurrence of any component of a composite of major adverse cardiovascular events (MACE) consisting…
Our first objective is obtaining hypertrophic myocardial tissue for identifying novel biomarker, indicative and predictive for the severity of cardiac hypertrophy. Our second objective is validation of biomarkers detected in previous studies.