129 results
The main objective of this part of the study (Work Package 1, WP1) which is part of a n European Union funded FP7 project entitled EUCLIDS is to develop, maintain and regulate the clinical network required to collect clinical data and patient…
Primary objective: To determine the effect of hyperbilirubinemia on systemic activation of the innate immune response induced by a lipopolysaccharide (LPS) challenge. Secondary Objective(s): - To determine if hyperbilirubinemia shifts the pro-anti…
To determine the genetic risk of susceptibility to, or severity of community-acquired pneumonia by comparing the interpersonal genetic variation of the host immune response of patients with community-acquired pneumonia to healthy controls and by…
1. To determine, in patients treated with TNF α blockers and living in the Q-fever endemic area, the prevalence of antibodies against C. burnetii and the prevalence of chronic Q fever.2. To assess other determinants in this group of patients which…
Primary objectives:- Evaluation of the value of mBL as a diagnostic tool for bacterial endocarditis.- Evaluation of the value of mBL as a monitoring tool during treatment for bacterial endocarditis.- To obtain data on the kinetics of mBL related to…
The principal goal of this study is to identify whether and how innate immune host factors predispose to the development of chronic Q-fever.
The elucidation of T-cell immune responses as well as IgE and IgG subclass antibody responses in children reporting severe local side effects after the fifth ACV vaccination as a component of the DTP-IPV combination vaccine. These responses will be…
To assess periodontitis-with P. gingivalis in particular- as a pathogenic factor in disease progression of RA.
To investigate the diagnostic properties of Borrelia immunoblots from various manufacturers and compare the diagnostic properties of different bands, and to validate the diagnostic value of B. burgdorferi PCR on blood and urine.
Confirm an association between RA and periodontitis and unravel pathogenic mechanisms underlying this association.
To determine the presence of ACPAs in patients with generalized severe periodontitis. Second objective is to assess RA development of ACPA positive periodontitis patients in the future.
1. The primary aim of the study is to investigate whether periodontal treatment results in a decrease of plasma biomarkers that are related to cardiovascular diseases (CVD) and metabolic syndrome (MS) and what is the effect of the treatment on the…
The primary objective of this study is to determine the prevalence of V-MRSA in areas with high density of pig farming compared to the expected prevalence of MRSA in the general population of The Netherlands and as a secondary objective to assess…
The primary objective is to compare the efficacy of moxifloxacin 400 mg PO OD for five days with the respective efficacy of amoxicillin clavulanic acid 875/125 mg PO BID for seven days in the treatment of subjects with AECB. The primary efficacy…
Primary objective: To determine the dynamics of MRSA carriage in persons working on or living at pig and veal farms.Secondary objectives: To determine the amount of disease associated with carriage of MRSA-CC398. To determine the role of exposure to…
Main objective: To compare the renal elimination rate constant in CF patients receiving a daily intravenous dose of tobramycin in the morning against patients receiving a daily intravenous dose of tobramycin in the evening. Secondary objective: To…
To study the effect of ethanol lock therapy on the cure rate of catheter-related infections (CRIs) and on the incidence of (CRI related) venous thrombosis in pediatric total parenteral nutrition (TPN) patients with tunneled central venous catheters…
The objective of this study is to identify determinants, to determine the transmissibility and to determine the burden of disease of NT-MRSA and CA-MRSA carriage compared to other typeable MRSA strains in the community.
The goal of this trial is to confirm that eradication rates obtained with Pylera are compatible to those obtained with the current European gols standard, OAC 7 days. This trial will constitute a pivotal trial leading eventually to approval of…
Primary Objective: To compare ketanest induction and maintenance to etomidate induction and maintenance with midazolam and fentanyl on hemodynamic, ventilatory and endocrine parameters during the first 2h after the diagnosis of sepsis and in need of…