8020 results
The primary objective is to demonstrate superiority in overall survival of amrubicin (40 mg/m2 administered as a 5-minute infusion once daily for 3 consecutive days starting on Day 1 of a 21-day course) compared with topotecan hydrochloride (…
Discrimination of probable AD patients from healthy volunteers by ZK 6032924 PET imaging as evaluated by visual analysis of the brain distribution patterns and by SUV values in probable AD patients as compared to healthy volunteers for brain imaging…
The aim of the proposed research is to test, by the use of functional magnetic resonance imaging, the hypothesis that psychometric schizotypy (referring to, e.g., subclinical hallucinations in healthy people) is associated with reduced activation of…
To study the effects of Mindfulness training in adults with ADHD on ADHD symptoms and comorbidity with affective and anxiety symptoms. Also, the feasibility of Mindfulness training will be evaluated in this specific patientgroup and the effect on…
To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.
Obtain normal values of ventricle volumes and CSF circulation in healthy volunteers with MRI scanning.
The primary aim of the study is to identify breast cancer patients who experience objective and/ or subjective cognitive dysfunction one year after chemotherapy and find determinants of this cognitive dysfunction on patients' quality of life…
The aim of the study is to compare magnesiumhydroxide and polyethylene glycol/electrolytes with regard to the prevention of constipation and side-effects in palliative care cancer patients starting with opioids.
Primary Objective: To determine the accumulation of AGEs in the skin and serum of pregnant women with DM1, DM2 or GDM, in comparison to healthy pregnant women and non-pregnant women with DM1 or DM2 and to determine the accumulation of AGEs in the…
To assess whether close rectal restorative proctocolectomy with IPAA has a better outcome regarding postoperative vaginal vasocongestion and reported psychological and sexual functioning then IPAA by TME restorative proctocolectomy.
Primary:to assess the reduction of initial study drug Cmax after administration of 20 mg study drug 10% SRF using three modified formulations as compared to the current Phase 3 formulation in healthy volunteers.Secondary:to assess the safety and…
Discover diagnostic biomarkers for disease severity. Increase the insight in the epidemiology of viral infections in the primary, secondary and tertiary care facilities and in the pathogenesis of and immunological response against viral infections.
The primary goal of the proposed study is to investigate the dopamine D2 receptor binding potential in patients with body dysmorphic disorder (BDD) and patients with trichotillomania (TTM) in comparison to healthy subjects. As BDD and TTM are OC…
The aim of this study is to demonstrate which is the most effective operation for neonates with necrotizing enterocolitis (NEC): intestinal resection with stoma formation or intestinal resection with primary anastomosis.
A pilot feasibility study (n=5) will be performed to evaluate the feasibility (logistics, timing) and safety of administering autologous tumor infiltrating lymphocytes (TIL) generated at the NKI-AVL infused in conjunction with systemic high-dose…
Primary objectiveThe objective of this pilot study is to test the hypothesis that the use of individual head supports will result in an actual given dose to both the target volumes as well as organs at risk that corresponds better to the planned…
How friendly is Delta-dry to the skin versus regular padding?Will Delta-dry be more functional than regular padding in patient experience? (Functional as in daily activity's concentrated to getting wet of the cast) How is the processability of…
The overall aim of the study is to evaluate the difference in speech performance of a new hands-free speech valve as compared to the currently most used (Atos) exhalation speech valve.
With this project we aim to clarify the differences in airway pathophysiology between asthmatics and healthy controls that underlie the prolonged survival of virus and the exaggerated inflammation in virus-induced exacerbations of asthma. We will…
The objectives of the study are:Developing an experimental design to obtain empirical data about the effects of a drama intervention on anxiety and mood disorders of adolescents.