349 results
To assess the association between baseline blood pressure and change in neurocognitive functioning after four years, and to assess whether baseline MRI phenotypes are predictive for changes in neurocognitive functioning after four years in the DANTE…
Objective 1: To prospectively evaluate the utility of C-FLOW monitor to examine status of regional CBF and reperfusion in patients presenting with acute anterior circulation ischemic stroke syndrome. Objective 2: To assess the feasibility,…
Primary objective: Determine for different control algorithms whether the algorithm is effective in providing the patient with the required support and bringing about the desired changes in the walking patternSecondary Objective(s): - Determine…
The primary objective of this study is to explore user acceptance of the HiM system in the usability study and to examine changes in functional use of the hand during ADL after prolonged use of a wearable robotic device by stroke patients in the…
Primary objectives:1. What is the effect of walking on a treadmill compared to walking in a patient-in-charge mode on kinematics in healthy subjects?2. What is the effect of walking on a treadmill compared to walking in a patient-in-charge mode on…
The objective of this feasibility study is compare the smart AFO + standardized shoes to subjects* own AFO + own shoes. Subjects* experiences with the orthotic devices will be evaluated and points for improvement will be asked. Subjects* performance…
This protocol is the next step in development of a reproducible technique for the quantification of CBF using simultaneous ultrasound at the internal carotid artery. We hypothesize that simultaneous measurement of the contrast signal in the internal…
The main objective of this study is to assess the effect of an acute cardiovascular event on the local and the systemic inflammatory state in humans with AMI as well as the reversibility of these effects after 3 months.
To ascertain the hypothesis that T-cell inflammation in the vascular wall of an unruptured intracranial aneurysm can be accurately detected with 18F-IL2 PET (proof-of-concept).
Explore difference in perforating artery pulsatility index between two patients groups with small vessel disease (history of lacunar infarct and deeply located haemorrhage) and healthy controls.
The overall aims of the proposed project are 1) to establish biomarkers for identification of the underlying vascular disease in patients with ICH and 2) to characterize whether disruption of the blood-brain barrier, a key factor in secondary brain…
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic RVCL disease carriers, in order to find a *biomarker* for disease stage and progression.
The primary objective of this study is to examine the direct influence of the grasp support system on (functional) performance and movement execution of the most-affected arm and hand. Secondary objectives are to examine the direct effect of the…
The aim of the present study is to investigate the added-value of reduction of early signs of spasticity in the upper extremity on improving functional arm-hand skill performance in sub-acute stroke patients with either a severely or moderately…
Main study objective of this study is:To evaluate whether the 320-detector volumetric CT technology can replace carotid duplex scanning and TEE in the diagnostic workup in TIA/IS patients. Specific aims of this main study objective are:1. To assess…
Primary Objective: To assess which measures of microvascular function on 7T MRI are affected in patients with CADASIL, relative to controls.
To assess the efficacy of a TCC, a BTCC and a cast shoe with similar plantar soles on offloading the previous ulcer location in people with DM and peripheral neuropathy.
To assess the sensitivity and negative predictive values of D-dimer- and FXIII activation peptide (AP-FXIII) values in order to exclude to exclude CVT in patients with clinical suspicion of CVT.
Determining the diagnostic value of CTA in patients with acute headache and normal neurological examination and head CT by performing a prospective study. Charting patient characteristics in order to more purposefully apply the CTA and avoid…
[1] To develop robust assays for quantification of novel CSF/blood biomarkers of CAA.[2] To determine the contribution of CAA to cognitive decline in dementia and ICH patients, using CAA-specific biomarkers