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Study of the genetic causes of disorders of the aorta, arteries and cardiac valves

To gain a better insight into the genetic factors that play a role in the etiology of the thoracic aortic aneurysm with the following specific aims:1. Study of specific geneitc factos that play a role in the pathogenesis of both syndromic and non-…

Immune response against Coxiella burnetii in Chronic Q-fever

The principal goal of this study is to identify whether and how innate immune host factors predispose to the development of chronic Q-fever.

Intracranial aneurysms: searching for markers of instability and risk of rupture

The main goal of the current study is to gain insight in the development and rupture rate of aneurysms and to detect potential markers that predict the risk of aneurysm rupture.

Linkage analysis in families with aortic aneurysm

The aim of the study described in this protocol is the identification of genes involved in aortic aneurysm development. This will be achieved by characterization of large AA families, including pedigree investigations, diagnostic measurements (…

@neurIST
Integrated biomedical informatics for the management
of intracranial aneurysms

To establish an operational reference database on intracranial aneurysms encompassing clinical and genetic data on at least 800 patients, 400 controls and 400 relatives of patients where a familial trait is recognized, together with imaging data on…

4D flow hemodynamics in the great arteries in children and adults after arterial switch operation for transposition of the great arteries

1. The application of 4D flow MR imaging to analyse blood flow patterns (flow angle, flow asymmetry), regional vessel wall parameters (regional wall shear stress, vessel wall thickness) and pulsed-wave velocity in neoaortic root, carotid artery and…

TSPO PET tracing In patients with and without Cognitive impairment in the long-term after AneurySmal Subarachnoid haemorrhage

To determine whether reactive gliosis persists >3 years after SAH and whether this response relates to cognitive impairment after SAH.

Endothelial Colony Forming Cells, Endothelial Progenitor Cells and Bicuspid Aortic Valves: in vitro culture of peripheral blood cells to study biomarkers and pathogenesis in BAV?

The main objective of this study is to find biomarkers for the prognosis of the BAV patients by investigating ECFC and EPC functioning, and to gain knowledge on physiological and pathological processes in patients by investigating molecular…