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A Randomized multicenter clinical trial of Unruptured Brain AVMs

Primary: To determine whether medical management improves long-term outcomes of patients with unruptured BAVMs compared to invasive therapy (with endovascular procedures, neurosurgery, or radiotherapy, alone or in ombination). The trial has been…

Exercise versus angioplasty for claudication based on iliac artery lesion

Primary objective of this study is to assess the treatment outcomes in terms of mobility parameters.Secondary objective is to assess the level of functional status and health-related quality of life.

The Impact of Intraoperative Carbon Dioxide Wound Ventilation on Cerebral Microembolic Load during Aortic Arch Surgery : a Prospective Randomized Clinical Trial using Transcranial Doppler Ultrasound

The primary objective of this study is to evaluate the impact of carbon dioxide field flooding on the quantitative intraoperative microembolic load of the brain during aortic arch surgery.A secondary objective is to evaluate any concomitant…

VESPA Trial: Endovenous laser treatment versus crossectomy of the small saphenous vein.

This randomized trial will compare EVLT with saphenopopliteal ligation with regard to therapy failure (a) and recurrence (b). a. Insufficiency of the SSV determined by ultrasound 6 weeks post-treatment is regarded as a therapy failure. b.…

Haemorrhoidal Artery Ligation Study: the surplus value of the Doppler

The objective is that 6 standard ligation of hemorrhoidal arteries is as effective as doppler guided.

Randomized Evaluation of dabigatran etexilate Compared to warfarIn in pulmonaRy vein ablation: assessment of an uninterrupted periproCedUral alntIcoagulation sTrategy (The RE-CIRCUIT Trial)

See section 2.2. of the protocol.The primary objective of this trial is to assess the safety of an uninterrupted dabigatran etexilate periprocedural anticoagulant regimen compared to an uninterrupted warfarin regimen in NVAF patients undergoing AF…

Catheterization of the radial artery with fixated ultrasound transducer

Primary Objective: Investigate whether fixation of the ultrasound probe, thereby freeing both hands for needling, improves performance of radial artery punctureSecondary Objective(s): Investigate whether fixation of the probe will lead to decreased…

The Efficacy of Pro- and Anticoagulant Therapy in Plasma of Patients with Cirrhosis undergoing Orthotopic Liver Transplantation

To investigate the in vitro effect of both pro- and anticoagulation therapy on thrombin generation by Calibrated Automated Thrombography in plasma from patients with cirrhosis undergoing liver transplantation.

SAFE: Sequre for Adenomyosis and Fibroid Embolisation

The aim of this research is to test the efficacy and safety of a new microcatheter 2.8F Sequre for treatment of uterine fibroids and/or adenomyosis with a standard embolization technique and to demonstrate the added value of this catheter, namely to…

PROTECTED TAVR: Stroke PROTECTion with SEntinel During Transcatheter Aortic Valve Replacement

The objective of this study is to demonstrate that use of the Sentinel® Cerebral Protection System significantly reduces the risk of periproceduralstroke (*72 hours) after transcatheter aortic valve replacement (TAVR).

PEERLESS study

The primary study objective is to compare the clinical outcomes of patients treated with the FlowTriever System versus Catheter-Directed Thrombolysis (CDT) for use in the treatment of acute intermediate-high-risk pulmonary embolism (PE).

A Randomized Trial comparing the Drug-Eluting Stent (DES) Below-the-Knee (BTK) Vascular Stent System (DES BTK Vascular Stent System) vs Percutaneous Transluminal Angioplasty (PTA) Treating Infrapopliteal Lesions in Subjects With Critical Limb Ischemia

Primary objective: To demonstrate a superior patency rate and acceptable safety rates in below the knee arteries with lesions treated with the DES BTK Vascular Stent System vs percutaneous transluminal angioplasty. (PTA). Secondary objective: To…

Optimizing Access Surgery In Senior hemodialysis patients

To compare surgical strategies for vascular access creation in elderly hemodialysis patients.

Uterine artery embolization versus hysterectomy for symptomatic adenomyosis: a case-control study

This study aims to evaluate the impact of UAE on Quality of life (QOL) in comparison to hysterectomy in adenomyosis patients. A cost-effectiveness study will be part of the trial as well as a cohort hysterectomy group to clearify imaging and…

Quantitative Magnetic Resonance imaging modalities in the assessment and determination of PORTAL hypertension study

The study aims to determine the feasibility and diagnostic accuracy of quantitative Magnetic Resonance Imaging (MRI) techniques for determining the presence of portal hypertension in patients with severe liver disease. The secondary objectives are…

Anatomical mapping and assessment of tissue perfusion using indocyanine green near-infrared fluorescence in patients with peripheral arterial disease.

The main objective of this study is to asses the applicability and validity of ICG parameters in the diagnostic work-up in patients with peripheral arterial disease. We will also asses the applicability of ICG-NIRF in intra-operative assessment of…

Prevention of PostAmputation Pain with Targeted Muscle Reinnervation (PreventPAP trial): A national, multicenter, randomized, sham-controlled superiority trial, comparing standard neurectomy with targeted muscle reinnervation in amputations of the lower extremities.

To compare postamputation pain (phantom limb pain and residual limb pain) one year postoperatively in patients receiving a lower extremity amputation with standard neurectomy versus those who received targeted muscle reinnervation.

Flow dysfunction of hemodialysis vascular access: a randomized controlled trial on the effectiveness of surveillance of arteriovenous fistulas and grafts

See above.

Randomized controlled clinical trial on the application of Heli-FX EndoAnchors in conjunction with the Endurant II/IIs endograft in infrarenal aortic aneurysms with a wide infrarenal neck

The primary objective of this study is to investigate if the use of Heli-FX EndoAnchors in conjunction with placement of aortic stent grafts under instructions for use (IFU) conditions in aneurysms with a wide neck is superior to treatment with…

Cannulation of the radial artery with three dimensional biplanar versus conventional two dimensional ultrasound guidance

Compare performance of radial artery catheterization using three dimensional biplanar ultrasound guidance versus conventional two dimensional US