335 results
This current study aims to investigate the use of bèta-TCP, a synthetic tricalcium phosphate, as a filler of the autologous symphyseal bone graft harvest site in patients undergoing grafting of clefts of lip, alveolus and palate.The specific…
The major aim of this project is to elucidate the molecular basis of IgAN. A large cohort of IgAN patients will be screened on aberrancies in the DNA sequence or expression of the gene encoding Cosmc, a protein that is essential for the biosynthesis…
An explanation of the complete spectrum of anomalies seen in fetuses with increased NT could be a disturbed endothelial differentiation related to the cardiovascular development. Cardiac defects form the severe end of the spectrum. More data, both…
Primary objective: *What is the effect of an incremental maximal exercise test on inflammation in patients with cystic fibrosis and in healthy people?*Secundary objectives:- What are the differences in basal immune values between HP and CF patients…
Speckle Tracking Imaging is a relatively new echocardiographic technique to quantify the left ventrikular twist and untwisting movement. Several populations like healthy adults and patients with hypertension, myocardial infarction or valvular…
To detect B-cell differentiation and maturation defects in patients with antibody deficiency syndromes of unknown origin (CVID, SAD), which are predictive for clinical complicationsTo detect and sequence candidate genes in subgroups of patients with…
1. To compare velocity encoded MRI and tissue Doppler echocardiography in the assessment of cardiac dyssynchrony2.To define the presence and degree of RV mechanical dyssynchrony in patients with corrected tetralogy of Fallot with RV dysfunction…
Since muscle biopsy is a invasive and risky operation, we hope to find a new way to diagnose mitochondrial disorders.
To test the hypothesis whether the Intima Media Thickness differs between FH carriers without apparent dyslipidemia and the group of FH carriers with apparent dyslipidemia and a control group consisting of persons tested by the StOEH who did not…
The aim of the present study is to evaluate the long-term pulmonary sequelae, exercise endurance and perception of exercise endurance in adult CDH patients in a cohort that has been studied earlier at a median age of 11.7 years. Lung function…
Primary aims:1. To perform a population-based screen to estimate the exact frequency ot transient leukemia in Dutch newborns with Down syndrome2. To investigate the realtionship between transient leukemia and the occurrence of DS ML and ALL at later…
The main objective is to identify a difference in mRNA expression level of IFN and IFN related genes between Down Syndrome children and a control group of healthy children (siblings). The secondary objective is to identify a relationship between…
To assess the skeletal health of FAP patients.
We set out to evaluate the genetic basis of dyslipidemia and cardiovascular disease.
The primary objective of the present study is to increase our insight in the neural processing of speech in pre-lingually deaf CI patients regarding the prediction and explanation of postoperative differences in performance within this specific…
Our objective is to measure systemic glycocalyx volume in patients with premature atherosclerotic disease before the age of 40 years and to compare this with a age and sex matched healthy control group.
The purpose of the study is to identify the molecular defects of CORD, to evaluate the clinical course as a function of the molecular defect, and to assess the modifying role of environmental factors.
The primary oblective of the study is to elucidate all molecular mechanisms leading to coeliac disease.In order to establish the scientific basis for the development of improved diagnostics, novel therapies and safer foods for patients, in the CDC:…
The purpose of the present study is to try to classify autistic children into distinct subgroups, by clinical morphological examination. We mainly want to answer the following questions: 1) Is there an increased prevalence of minor anomalies in…
The main objective is to understand the role of the noradrenergic system in human cognition by testing specific hypotheses about task performance in D*H patients. A secondary objective is to understand whether and how cognitive function is…