Search for a trial

Preventing contrAst induced Nephropathy after TranscathEter aortic valve Replacement

To evaluate the efficacy of 250ml 1.4% sodium bicarbonate versus hypotone saline hydration prior to TAVI in patients with CKD to prevent CIN.

Cost-effectiveness of a lifestyle intervention on health and sustainable employability among workers of 40 years and older with high physical work demands: a randomized controlled trial

- to evaluate (cost-) effectiveness of a personalized health intervention among workers of 40 years and older with high physical work demands to contribute to a reduction in CVD and sustainable employability.

Bioprofiling response to mineralocorticoid receptor antagonists for the prevention of heart failure. A proof of concept clinical trial within the EU FP 7 *HOMAGE* programme « Heart OMics in AGing

Main objective: To investigate whether spironolactone can favourably alter extra-cellular matrix remodelling, assessed by changes in the fibrosis biomarker Procollagen Type III N-Terminal Peptide (PIIINP), in patients at increased risk of developing…

An OPen-label, Randomized, Controlled, Multicenter Study ExplorIng TwO TreatmeNt StratEgiEs of Rivaroxaban and a Dose-Adjusted Oral Vitamin K Antagonist Treatment Strategy in Subjects With Atrial Fibrillation Who Undergo Percutaneous Coronary Intervention - PIONEER AF-PCI

In this study, the main clinical hypothesis is that the TIMI clinically significant bleeding rates will not be different between the rivaroxaban and VKA treatment strategy groups at Month 12.

European Fans in Training (EuroFIT): A multicentre randomised controlled trial of a gender-sensitised programme to increase physcal activity and reduce sedentary time delivered to men aged 30-65 in elite European football clubs

The main aim of the EuroFIT trial is to assess the effectiveness and cost-effectiveness of the EuroFIT programme in supporting men to achieve an increase of at least 1000 steps per day (about 10 minutes on average per day, or 70 minutes per week)…

The Lipid-Rich Plaque Study

The Lipid-rich Plaque Study will be performed in patients undergoing IVUS-NIRS imaging (the index procedure) in whom a TVC catheter will be purchased and used for routine clinical indications. The study will test the ability of multi-vessel NIRS…

Effects of VERApamil versus metoprolol to prevent progression from Paroxysmal to persistent Atrial Fibrillation

We hypothesize that verapamil reduces progression from paroxysmal to persistent AF, improves rate control, exercise tolerance and quality of life and reduces costs compared to metoprolol.

Effects of dietary sodium restriction on blood pressure in renal transplant recipients: an intervention study

Primary Objective: •To investigate the effect of dietary sodium restriction on blood pressure and use of antihypertensive medication in renal transplant recipients.Secondary Objective(s): •To investigate the effect of dietary sodium restriction on…

A RANDOMIZED, OPEN-LABEL, MULTI-CENTER, ACTIVE-CONTROLLED, PARALLEL GROUP STUDY TO DETERMINE THE EFFICACY AND SAFETY OF THE REG1 ANTICOAGULATION SYSTEM COMPARED TO BIVALIRUDIN IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION

Primary To determine the efficacy of REG1 compared to bivalirudin in patients with coronary artery disease (CAD) undergoing Percutaneous Coronary Intervention (PCI) for preventing the composite of death, nonfatal myocardial infarction, nonfatal…

The effects of on the rheologic properties and oxygen transport capacity of red blood cells processed by 3 different types of cell savers, and its effects on microcirculatory blood flow and tissue oxygenation in vivo

The objective of this study is to determine in vitro the rheologic and oxygen transport capacity of the washed blood processed by one of 3 different cell savers and to measure in vivo after retransfusion of this processed blood in the patient the…

Finding the optimal treatment of severe panic symptoms in patients presenting at the emergency department with non-cardiac chest pain or palpitations. A cognitive behavioural therapy based intervention versus an information sheet. A randomized controlled trial.

The objective of our study is to examine the effectiveness of a cognitive behavioural therapy based intervention compared to an information leaflet on anxiety symptoms after one month, in patients presenting at the emergency unit with non-cardiac…

A Prospective, Randomized Evaluation of the TriGuard* HDH Embolic DEFLECTion Device during Transcatheter Aortic Valve Implantation

To assess the safety, efficacy, and performance of the TriGuard HDH embolic deflection device in patients undergoing transcatheter aortic valve implantation (TAVI), in comparison with patients undergoing unprotected TAVI.

After the Health Check in vulnerable groups: an individually tailored self regulation intervention led by Community Health Workers.

The overall objective of this study is to increase the uptake and maintenance of healthy behaviors among adults from non-Western immigrant populations who are identified as having a high risk of cardiometabolic disease after completing a health…

Optimising the effects of exercise in diabetes

We will identify factors that interfere with the beneficial effects of exercise on the vasculature in T2DM.

Clinical evaluation of Remote monitoring with dirEct Alerts* to reduCe Time from event to clinical decision

St. Jude Medical developed the Merlin.net* Patient Care Network (Merlin.net* PCN) to augment or replace routine scheduled in-clinic visits. This investigation is designed with the hypothesis that detection of events (system integrity and diagnostic…

Catheter ablation versus Amiodarone to pRevent Future ventricular tachycardia Episodes in patients with a defibrillator and a history of a myocardial infarction

Time to recurrence of sustained VT and/or appropriate ICD therapy; ATP or shock

A Prospective, Randomized, Double-Blind, Double-Dummy, Parallel-Group, Multicenter, Event-Driven, Non-inferiority Study Comparing the Efficacy and Safety of Once Daily Oral Rivaroxaban (BAY 59-7939) With Adjusted-Dose Oral Warfarin for the Prevention of Stroke and Non-Central Nervous System Systemic Embolism in Subjects With Non-Valvular Atrial Fibrillation (39039039AFL3001)

The primary objective of this study is to demonstrate that the efficacy of rivaroxaban, a direct FXa inhibitor, is non-inferior to that of dose-adjusted warfarin for the prevention of thromboembolic events in subjects with non-valvular atrial…

Effectiveness of a trainingsprogram on the metabolic syndrome, heart failure and cognition in institutionalysed elderly.

The objective of the study is to investigate effects of training on insulin resistance (IR), chronic heart failure (CHF) and cognition of resthome residents.

OPTImal CArdiac REhabilitation (OPTICARE) following Acute Coronary Syndromes: A multicenter, randomized, controlled trial to investigate the benefits of an expanded educational and behavioural intervention program.

Primary objective of the OPTICARE study is to evaluate whether patients with acute coronary syndrome (ACS) will derive additional benefit from an extended CR program compared to standard CR.

Effects of a nurse coordinated program of lifestyle improvement aimed at reducing the risk of recurrent cardiovascular events in patients who have suffered an acute coronary syndrome.;RESPONSE2: (Randomised Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists 2)

Primary Objective: To determine the effectiveness of a comprehensive lifestyle intervention program aimed at reducing the risk of recurrent cardiovascular events in patients who have suffered an acute coronary syndrome.Secondary Objective:…