49 results
To assess whether the iFR is non-inferior to FFR when used to guide treamtent of coronary stenoses with PCI
To compare the diagnostic value of CTA versus the standard work-up in terms of identifying patients with severe coronary artery disease (requiring revascularization), as well as the ability to safely discharge patients without coronary artery…
The overall aim of the study is to demonstrate that a comprehensive cardiac CT examination improves the diagnostic workup of stable chest pain in terms of accuracy, efficiency and costs. In concrete terms, the purpose of this randomized controlled…
Demonstrate that with contemporary cardiac CT scan protocols good opacification of the coronary arteries can be achieved, that is similar to low-osmolar contrast media injected at the same iodine delivery rate. In addition, we will investigate the…
- Our primary objective is to analyze if MR perfusion imaging can guide therapy, improve patient safety and reduce costs. - The secondary objective is to determine the optimal therapy for patients with stable angina.
Primary objective: To investigate whether urine prothrombin fragments are increased in individuals suffering from VTE (i.e. PE or DVT) or a myocardial infarction compared to healthy matched controls.Secondary objective: to investigate whether…
The goal of this study is to find an efficient early diagnostic and prognostic marker of myocardial ischemia and myocardial infarction. Extended screening of gene expression profiles in circulating progenitor cells in the peripheral blood of…
Objective:The hypothesis of this study is that laboratory markers for blood coagulation, platelet activity and inflammation may help to identify patients at risk for a recurrent cardiovascular event after ACS. Secondary, we expect to find…
We will investigate if irradiation of part of the heart leads to cardiac sympathetic innervation injury and subsequently to radiation induced cardiovascular disease.
The objective for this trial is to evaluate an invasive strategy using urgent PCI (<3h) as compared to an early PCI (24h) using novel quick acting antiplatelet therapy.
To test the non-inferiority of the Synergy* abluminal coated everolimus eluting stent with bio-absorbable polymer from Boston Scientific compared to the Nobori* abluminal coated biolimus eluting stent with bio-absorbable polymer from Terumo in the…
To evaluate whether primary percutaneous coronary intervention (primary PCI) with a new thrombectomy device as compared to primary PCI without thrombectomy increases minimal flow area after stenting for treatment of patients presenting with ST-…
Our primary objective is to measurec glycocalyx volume with OPS imaging, before and after sublingual nitroglycerine-spray administration, in patients with premature atherosclerotic disease before the age of 40 years and a positiev family history for…
Primary Objective: To demonstrate that IVUS with VH guidance leads to better post procedural outcome when compared to angiographic guidance only.Secondary Objective:To demonstrate that IVUS and VH guidance leads to lower occurrence of MACE at short…
The primary aim of this MAPCAT-study is to investigate whether pharmacokinetics of clopidogrel differ significantly betwen different clinical scenarios. A second aim is to study specifically whether genetic polymorfisms influence these…
To investigate the relation between premature cardiovascular disease and glycocalyx perturbation
We designed a trial to evaluate a new diagnostic approach to suspected CAD with consideration for thecontemporary insights towards the management of CAD, which incorporates plaque imaging for prevention of adverse events,and maintains a role for…
To establish whether miRNA expression patterns in platelets, monocytes and plasma differ between subjects with premature CVD and a positive family history of premature CVD as compared to age en sex matched healthy controls.
The aim of the present study is to investigate if FFR measurement of a stenosis in a remote coronary artery are influenced by the presence of acute myocardial infarction.
Our objective is to measure systemic glycocalyx volume in patients with premature atherosclerotic disease before the age of 40 years and to compare this with a age and sex matched healthy control group.