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Observational multi-center, prospective study to develop a novel multi-parametric diagnostic model for hospitalized patients and patients on the Emergency Department presenting with lower respiratory tract infections and/ or sepsis.

To develop a novel multi-parametric diagnostic model for the management of patients with LRTI and/or sepsis that will be based on novel pathogen- and host-related factors.

Long-term StaphyloCoccus aureus decolonizAtion in patients on home parentRal nutRition: a randomized multicEnter tRial.

To identify the most effective and safe long-term S. aureus carriage decolonization strategy in HPN patients. Ultimately this willlead to less antimicrobial resistance, less catheter removals and lower mortality rates. Also, other chronic…

Community Acquired Pneumonia: Outcome, Quality of Life and Immune Status

The aim of this study is to investigate immune response to pneumococcal vaccination in patients after community acquired pneumonia with S. pneumoniae compared to pneumonia patients with another pathogen.

Understanding Q-detect: Coxiella burnetii exposure and the humoral and cellular immune response

(i) to determine specificity of Q-detect* for registration purposes. (ii) to design a decision tree for follow-up of patients with a positive Q-detect* and

Molecular detection of the bacterial load as a diagnostic and monitoring tool for optimal antibiotic treatment in endocarditis

Primary objectives:- Evaluation of the value of mBL as a diagnostic tool for bacterial endocarditis.- Evaluation of the value of mBL as a monitoring tool during treatment for bacterial endocarditis.- To obtain data on the kinetics of mBL related to…

Comparison of assays for Borrelia detection

To investigate the diagnostic properties of Borrelia immunoblots from various manufacturers and compare the diagnostic properties of different bands, and to validate the diagnostic value of B. burgdorferi PCR on blood and urine.

Q Herpen II, Post outbreak screening in a Q fever high incidence area for late consequences of Q fever including chronic Q Fever.

This study will provide a robust estimate of the prevalence of C. Burnetii exposure and possible chronic Q fever among asymptomatic participants. This is important in order to assess whether population screening in a high incidence area is useful…

CRP-guided antibiotic treatment in patients hospitalized with acute exacerbation of COPD patients.
The CATCH (CRP guided Antibiotic Treatment in COPD exacerbations admitted at the Hospital) study.

OBJECTIVESIn this study CRP-guided antibiotic therapy will be compared with GOLD antibiotic therapy in AECOPD with special attention at consumption antibiotics and treatment failure.

Reducing the prescription of antibiotics in newborn infants suspected for having an early onset sepsis.

Our preliminary data shows that the prescription rate of antibiotics for suspected EOS versus blood culture proven EOS was high. We aim to develop a new diagnostic model to reduce unnecessary antibiotic treatment which can be tested in the near…

Determining the causative agent and optimal duration of antibiotic therapy in persons with diabetes and foot osteomyelitis: BonE BiOPsy (BeBoP) trial

Primary Objective: To prospectively compare outcomes of subjects with diabetic foot osteomyelitis treated with antibiotics targeted at culture results from bone biopsy (intervention group) versus therapy targeted at ulcer bed biopsy culture results…

Kinetics of immune responses and characteristics of antigen-specific B cells after Bordetella pertussis vaccination

This study is designed to dissect the immune response after Bp booster vaccination by investigating the kinetics of innate and adaptive immune cells, and detection and characterization of Bp-specific memory B cells and plasma cells.

Interferon gamma release assays for Q fever: Evaluation of new test formats in exposure screening to C. burnetii

The objective of the current study is to evaluate the performance of two new formats of the IGRA using pre-filled antigen formulations in a cohort of Dutch individuals with known prior exposure to Cb.

Pilot study to evaluate the potential value of Fluorescence In Situ Hybridization (FISH) of white blood cells for the diagnosis of Q fever fatigue syndrome

To evaluate whether Fluorescence In Situ Hybridization (FISH) on blood cells can distinguish patients with QFS from controls with no evidence of past Coxiella exposure and individuals with past asymptomatic C. burnetii infection.

Presepsin as diagnostic marker for bacterial infection in young infants with fever of unknown origin

This study aims to evaluate the role of presepsin in the diagnosis of bacterial infections in young infants with fever of unknown origin.

Diagnostic value of soluble CD14 subtype in neonatal sepsis

The aim of this study is to evaluate the diagnostic value of sCD14-ST in the diagnosis of neonatal sepsis. The secondary aim is to evaluate whether serial measurement of sCD14-ST after suspected sepsis onset is of additive predictive value for the…

Changes in host gene expression to differentiate between systemic inflammation and infection after major surgery (PAX study)

Primary Objective: To study the early diagnostic performance of specific gene signatures for differentiation of patients having postoperative infection (A1) or sepsis (A2) from non-infected patients having postoperative SIRS (B1) and non-infected…

The effect of rectal swab culture-guided antimicrobial prophylaxis in men undergoing prostate biopsy on infectious complications and cost of care: A randomized controlled trial in the Netherlands.

- To assess the effectiveness of rectal culture-guided antimicrobial prophylaxis for transrectal prostate biopsy (random ultrasound-guided, targeted MRI-guided or targeted MRI-ultrasound fusion guided) on infectious complications. - To compare the…

T-cell response in Lyme disease (TRIL-study)

Main objective: To determine the T cell response to Borrelia specific antigens using an ELISpot interferon gamma release assay in patients with different clinical presentations of Lyme and healthy volunteers.Sub-question 1: QuestionnairesTo analyze…

T cell respons in legionella

To evaluate the diagnostic potential of the elispot Legionella for identifying patients with Legionella disease

INTRAVENOUS-TO-ORAL ANTIBIOTIC SWITCH THERAPY FOR SUSPECTED NEONATAL BACTERIAL INFECTIONS: ;CLINICAL EFFICACY, SAFETY AND COST-EFFECTIVENESS

PRIMARY* To demonstrate the non-inferiority of intravenous-to-oral antibiotic switch therapy in clinically stable neonates with probable bacterial infection compared to a complete course of intravenous antibiotic therapySECONDARY* To describe the…