129 results
Could cytokines removal therapy by CytoSorb adsorber cause any improvement in the microcirculation?
To determine the superiority of doxycycline-rifampicin compared to trimethoprim-rifampicin for the decolonization treatment of complicated MRSA carriership.
- To assess the effectiveness of rectal culture-guided antimicrobial prophylaxis for transrectal prostate biopsy (random ultrasound-guided, targeted MRI-guided or targeted MRI-ultrasound fusion guided) on infectious complications. - To compare the…
To investigate whether minimally processed milk product can decrease the diarrheagenic E. coli-induced changes in reported stool frequency and gastrointestinal complaints.
The primary objective of this study is to examine clinical and radiographical parameters when executing:- adjuvant antibiotic therapy versus no antibiotic therapy in the resective surgical treatment of 0-, 1- and 2-wall bone defects due to peri-…
Investigation of the impact of a treatment consisting of inhalation antibiotics and prolonged oral antibiotic course during a bacterial exacerbation on the prevention of further exacerbations.
The main objective of this study is to determine differences in vaccine responses in the pre-elderly age group (50-65 years of age) to a primary immunization with vaccine antigens to which no or (very) low pre-vaccination antibody levels and memory…
Primary Objectives: 1.To obtain insight in the role of altered DNA methylation in blood leukocytes (monocytes and neutrophils) in innate immune responses and host defense in patients with CAP.2.To determine the composition and function of the gut…
Main objective: To determine the T cell response to Borrelia specific antigens using an ELISpot interferon gamma release assay in patients with different clinical presentations of Lyme and healthy volunteers.Sub-question 1: QuestionnairesTo analyze…
Primary Objective: - To study the pharmacokinetics (CL, Vd, and F) of ciprofloxacin in cachectic elderly patients and compare with normal weight participants.Secondary Objective(s): - To assess the influence of covariates (such as TBW, LBW, serum…
The aim of this multicenter open-label, randomized controlled trial is to investigate the superiority of 5 days (extended) versus a single dose of cefazolin prophylaxis in revision arthroplasty of the hip and knee.
Western Management strategies have been ineffective to modify the poor prognosis of GC. This proposal will focus on this specific challenge to *improve GC outcomes*, and will seek to gather evidence through international high-quality translational…
The primary objective is to determine the absorption of orally administered antibiotics in patients with SBS, to guide in clinical decision making when faced with catheter related infections.
To evaluate the diagnostic potential of the elispot Legionella for identifying patients with Legionella disease
Determine the efficacy of medical grade honey to reduce or prevent bacterial colonization at skin of intensice care patients.
The REPLACE study aims to determine whether not changing the catheter (catheter retained) for catheter-associated urinary tract infections (CAUTI)affects the recurrence-risk of CAUTI.
PRIMARY* To demonstrate the non-inferiority of intravenous-to-oral antibiotic switch therapy in clinically stable neonates with probable bacterial infection compared to a complete course of intravenous antibiotic therapySECONDARY* To describe the…
Primary objective: To assess microbiological, immunological, genetic, clinical, cognitive-behavioral, and epidemiological determinants for development of persisting symptoms in both adult and juvenile Lyme patients, and establish prediction rules *…
The objective of this study is to determine whether long term (5 days) postoperative (cefazolin) antibiotics will decrease the rate of infection following lower extremity tumor surgery, when compared to short term (24 hours) postoperative (cefazolin…
The objective of the study is to develop a whole blood cell-mediated immunity test for Borrelia infection and investigate whether such a test can detect Borrelia infections more reliably than the currently used antibody tests in the early stage of…