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Paediatric distal radius torus fracture treatment comparison in a prospective randomized control trial: mitella versus plaster cast

If the study shows that the treatment with a sling gives an earlier return to normal function en does not give a clinically significant difference in pain experience compared to cast therapy than the traditional treatment can be adjusted. We aim at…

Paracetamol or NSAID's in acute musculoskeletal syndromes

The objective of the current study is to compare three different strategies of pain management in patients presenting to an emergency department and to a general practice with acute musculoskeletal syndromes (defined as musculoskeletal complaints…

Evaluation of different wound dressings in the treatment of children with spoke injuries

To study wether a biodressing impregnated with polyhexamethylene biguanide in the treatment of spoke injuries in children could give a reduction in pain during the treatment compared to the standard treatment with wound dressing impregnated with

A multicenter, multinational, randomized, controlled, open label study, performed in children with thermal burns, to evaluate the efficacy and safety of NexoBrid as compared to standard of care (SOC) treatment

To evaluate the safety and clinical benefit of NexoBrid in hospitalized children (0-18 years) with deep partial and/or full thickness thermal burns of 1-30% TBSA and to compare NexoBrid to standard of care (SOC).

Moving with osteoarthritis: the effect of an altered gait pattern on knee load in persons with knee osteoarthritis

To investigate whether applying small changes to the gait pattern of patients with osteoarthritis lead to a reduction of the knee adduction moment in both the short term and long term.

Local gentamicin in Redon treated post-sternotomy mediastinitis

The aim of our study is to evaluate clinical outcomes of patients primarily closed over Redon catheters for the treatment of PSM, comparing the application of local gentamicin with a control group.

Clinical Application of a Dermal Substitute based on glycerol
preserved Allograft: GLYADERM®
A multicentre, prospective, controlled, randomized, comparative
trial of Glyaderm® and split thickness skin graft versus split
thickness skin graft alone in full thickness skin defects

Objective: The main objective is to evaluate the difference in scar quality, after skin restoration of full thickness defects treated with Glyaderm® and STSG versus STSG alone.Secondary objectives are: to evaluate the percentage of Glyaderm® take…

*Unilateral fracture of the mandible: a comparison of intermaxillary fixation with screws or arch bar*

The aim of the present study is to demonstrate the effectiveness of screw IMF.

Four-part fractures of the proximal humerus; conservative treatment or reversed type shoulder prosthesis

Our primary objective is to compare the short-term (one-year follow-up) clinical results of the DePuy Delta Xtend reversed shoulder prosthesis with conservative treatment, in the management of displaced four-part fractures of the proximal humerus of…

Potential Carcinogenic Effects of Endovenous Laser Ablation

This study will determine the concentration of benzo[a]pyrene before and after EVLA.

Same level fibular plating versus not plating in distal metaphyseal tibia fractures treated with intramedullary nails: a randomized trial.

Primary question:I. Does additional fibular plating lower the incidence of malalignment after surgical treatment of distal same level metaphyseal tibia and fibula fractures treated with locked intramedullary nailing?Secondary questions:I. Does…

Functional outcome after skin grafting of the burned dorsal hand in fist position with wrist in 30° flexion: evaluation of a new treatment protocol

1. To assess the feasibility of a new treatment protocol of skin grafting of the burned dorsal hand in fist position with wrist in 30° flexion per and post ok.2. To explore the effects of skin grafting on the burned dorsal hand in fist position with…

Randomised controlled trial comparing the LFN (Lateral Femoral Nail) to the UFN (Unreamed Femoral Nail) in the treatment of femoral shaft fractures.

1 Confirm comparable results in reduction and consolidation of the fracture fragments using the LFN vs the UFN2 Identifying a significant difference in the soft tissue damage between the LFN and the UFN

*Pain exposure* physical therapy versus standard therapy for patients with complex regional pain syndrome type 1 (CRPS-1)

Despite a lacking scientific argumentation, the PEPT approach or Macedonian therapy, is now being adopted on a large scale among physical therapists in The Netherlands for patients with CRPS-1. There are two level C retrospective cohort studies…

Ultrasound guided axillary nerve block compared to hematoma block for analgesia in patients with closed reposition of distal forearm fractures.

The primary goal of this study is to compare ultrasound-guided ANB with FHB for analgesia during closed reposition of distal forearm fractures. Secondary goals are evaluation of feasibility in the ED regarding time and procedure success rate.…

Clinical study of comfort, pain and time to return to previous activities with conservative treatment of clavicle fractures with a 2 point-sling or broad arm sling

ObjectivesThe aim of this study is to measure if there is a significant difference in comfort, pain and recovery of function between treatment with a broad arm sling or a 2 points-sling in patients with a collarbone fracture, treated conservatively.…

Repair versus reconstruction of proximal anterior cruciate ligament tears

The objective of this prospective randomized controlled trial is to compare the outcomes of arthroscopic primary repair of proximal ACL tears with the current gold standard of ACL reconstruction.

Dexamethasone for Cardiac Surgery II trial

The primary objective of this study is to study the effects of intraoperative dexamethasone administration on postoperative recovery following cardiac surgery.

Comparing Restrictive vs. Liberal Oxygen Strategies for Trauma Patients: The TRAUMOX2 Trial

The main aim is to compare the effect of a restrictive versus liberal oxygen strategy the first eight hours after trauma on the incidence of 30-day mortality and/or major respiratory complications (pneumonia and ARDS) within 30 days (combined…

A Randomized Controlled Trial on Prophylactic Platelet Transfusion Prior to Central Venous Catheter Placement in Patients with Thrombocytopenia

Our objective is to determine in a controlled study whether not correcting thrombocytopenia prior to CVC placement is non-inferior compared to correcting. In the Netherlands annually 17.700 units PC are possibly unnecessary transfused, for the…