94 results
We aim to gain insight into the incidence and severity of CIPN and its influence on patient-reported outcomes (i.e. health related quality of life (HRQoL), disease-specific complaints, depression, fatigue, sleep problems) among a prospective…
The objective is to compare the efficacy and safety of masitinib 12 mg/kg/day to sinutinib 50 mg/day
Safety and efficacy objectives:The objective is to compare the safety and efficacy of masitinib at 6 of 7.5 mg/kg/day to imatinib at 400 or 600 mg, in patients with gastro-intestinal stromal tumour in first line medical treatment.
We study whether addition of a radiation boost to standard chemoradiation in patients with locally advanced rectal cancer increases the complete response rate defined as pathological complete response in those who undergo surgery, or 2-years local…
EFFICACY OBJECTIVESWithin each cohort, the study has the following co-primary efficacy objectives:· Assessing early efficacy during the Maintenance Treatment Phase based on a 20%reduction in tumour size after 2 months of treatment· Evaluating PFSThe…
The primary objective of the study is to gain insight in the short term and long term effects of the EFCT-ODA therapy on 1) dyadic coping abilities in the relationship and 2) relational satisfaction. Moreover, the process aspects of the ODA will be…
Implementation of a biobank infrastructure to facilitate development and improvement of screening markers for colorectal neoplasia. New biomarkers will be compared to state of the art tests, e.g. currently FIT.
Comparing differentiation and detection of neoplasia in patients with ulcerative colitis undergoing surveillance, by ETMI and CE, in a randomised trial.
We aim to test the hypothesis that EndoCuff improves totaal number of adenomas detected and ADR compared with regular colonoscopy. In other words, we'll study if the Endocuff colonoscopy detects more polyps.
The goal of this study is to compare the efficacy and safety of the Wallflex stent to the Egis stent.
Feasibility and accuracy of the Olympus Extra Wide Angle View colonoscope for the detection of colorectal lesions in comparison with the Exera III study
Since imatinib easily and rapidly dissolves at pH 5.5 or less, a lack of gastric acid secretion might be causing the decreased exposure in the patients that underwent major gastrectomy. Therefore we would like to study if the exposure to imatinib in…
Purpose:We like to determine the movement of the intestinal contents to measure the peristaltic movement/ motility.
Primary Objective• For Arms A, B, and C: Determine the overall response rate (RR) of EZN-2208 for two distinct cohorts of patients with mCRC- Patients with mutated K-RAS tumors (Arm A)- Patients with wild-type K-RAS tumors (Arms B and C)• For Arms B…
Objective: To compare patient outcome following standard of care (laparoscopic right hemicolectomy) and an alternative, established, recognized therapy (SILS right hemicolectomy) for the treatment of right colonic tumors.
The purpose of this project is to perform a randomized trial comparing BARRX ablation with endoscopic surveillance for patients with a Barrett*s esophagus containing low-grade dysplasia. This study will also assess the effect of RFA ablation in…
Through a non-invasive cardiac output measurement we want to investigate in this observational pilot study , if it is possible to reduce the fluid intake in the first 24 hours (both perioperatively and postoperatively) by 30 %
Evaluation of the effectiveness of a new system HD2/NBI2 to improve the detection of colorectal neoplastic lesions during colonoscopy in comparison to the former generation with currently highest share of the installed base (nonHD-nonNBI system i.e…
The primary objective of this study is to evaluate the tumor response of stable disease (SD), partial response, or complete response at at 12 weeks (according to RECIST 1.1 criteria) in two separate cohorts representing molecularly distinct subsets…
Assessment of the detection of neoplastic lesions in patients with longstanding ulcerative colitis, using different endoscopic imaging techniques: A: Chromo-endoscopy, methylene blue 0.1% (HDTV Olympus)B: HDTV Olympus colonoscopes and NBIC: Chromo-…