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A multicenter study evaluating the diagnostic value for vascular abnormalities of High Definition Bronchoscopy when combined with i-scan Imaging Technology compared to High Defintion Bronchoscopy alone

Primary objective:Determing the positive predictive value and diagnostic yield of HD+ i-scan bronchoscopy for vascular pattern detection .Secondary objectives:1. To investigate the correlation of vascular abnormalities with histology2. To…

Respiratory signal driven breathing instructions to improve spatial alignment between respiratory gated PET and breath-hold CT

Is it possible to increase the spatial match between PET and CT imaging with the use of a respiratory instructed breath hold CT?

A phase III, multicenter, randomized, open-label study of oral LDK378 versus standard chemotherapy in adult patients with ALK-rearranged (ALK-positive) advanced non-small cell lung cancer who have been treated previously with chemotherapy (platinum doublet) and crizotinib

The primary objective is to compare the antitumor activity of LDK378 versus reference chemotherapy.The key secondary objective is to compare Overall Survival (OS) in patients treated with LDK378 versus reference chemotherapy (pemetrexed or docetaxel…

A phase III multicenter, randomized study of oral LDK378 versus standard chemotherapy in previously untreated adult patients with ALK rearranged (ALK-positive), stage IIIB or IV, non-squamous non-small cell lung cancer

The primary objective is to compare the antitumor activity of LDK378 versus reference chemotherapy

A Randomized, Open-label Phase 2 Clinical Trial of BMS-986012 in Combination with Carboplatin, Etoposide, and Nivolumab as First-line Therapy in Extensive-stage Small Cell Lung Cancer

This study has been transitioned to CTIS with ID 2024-510700-36-00 check the CTIS register for the current data. Study CA001-050 is a Phase 2 randomized, open label, multicenter clinical study designed to assess the safety and tolerability, of…

A Phase III, Randomized, Multicenter, Open-Label, Comparative Study to Determine the Efficacy of Durvalumab or Durvalumab and Tremelimumab in Combination With Platinum-Based Chemotherapy for the First-Line Treatment in Patients with Extensive Disease Small-Cell Lung Cancer (SCLC)

To assess the efficacy of durvalumab +tremelimumab + EP treatment compared with EP in terms of OS and the efficacy of durvalumab + EP treatment compared with EP in terms of OS

MicroRNA profiles in blood and urine in lung cancer: a pilot study

The primary objective of this study is to compare the profile of MicroRNA*s in the urine and blood of lung cancer patients with the profile of MicroRNA*s in the urine and blood of non-lung cancer patients with similar symptoms and with that of…

The benefit of ultra-high resolution computed tomography: Precision of repeated volume measurements of pulmonary nodules

To assess the variability of semi-automated volume measurements of pulmonary nodules in patients with known or suspected pulmonary metastases on same-day repeated scans of equal radiation dose from two different CT scanners: CT scanner with standard…

Characterization of Methylation Patterns in Lung Cancer (Lung-RND-001)

• Characterization of methylation patterns in blood samples and finding of methylation patterns that are unique to lung cancer.• Development of a molecular test for early diagnosis of lung cancer from a blood sample that will be more sensitive and…