66 results
This study has been transitioned to CTIS with ID 2024-515604-39-00 check the CTIS register for the current data. The purpose of this research study is to learn about the safety and effectiveness of 177Lu-PNT2002, an investigational agent being…
To determine wheter the use of the taurolidine 1.35%, citrate 4%, and heparin 100 IU/ml lock solution (TauroLock*-Hep100) reduces the incidence of first tunneled central line associated bloodstream inections (CLABSI) compared to the heparin 100 IU/…
Study MX39795 will compare the efficacy and safety of molecularly-guided therapy versusstandard platinum-containing chemotherapy in patients with poor prognosis cancer of unknown primary site(CUP; non-specific subset) who have achieved disease…
The research objectives of this study are divided in a primary research objective and secondary research objectives.Primary:1. To study the effectiveness on the short and long term of patient-tailored interdisciplinary MSCR compared with AHC on the…
The ultimate aim of this project is to provide scientific evidence on tailored psychological interventions for cancer patients with an adjustment disorder. This study investigated the effectiveness, cost-utility and budget impact of a tailored…
This study has been transitioned to CTIS with ID 2024-516631-27-00 check the CTIS register for the current data. The evaluation of R-IrAE's after ICI therapy, specifically incidence, treament of R-IrAE's, response to said treatment,…
This study has been transitioned to CTIS with ID 2023-507582-25-00 check the CTIS register for the current data. PRIMARY OBJECTIVESThe primary objective of MAKEI V is to assess in a randomized comparison whether the efficacy of Carboplatin (600 mg/…
Part BPrimary:• To determine the anti-tumor activity of NM21 1480 according to RECIST 1.1• To assess the safety and tolerability of NM21 1480 in patients with selected advanced cancers treated at or around the recommended Phase 2 dose (RP2D)• To…
PRIMARY OBJECTIVE: -To assess the antibody response after mRNA (Pfizer, Moderna) SARS-CoV-2 vaccination in children with cancerSECONDARY OBJECTIVES:To assess in children with cancer after SARS-CoV 2 vaccination:- durability of the antibody response…
To obtain a fundamental understanding if and which chemotherapeutic agents used for treating cancer during pregnancy are associated with offspring (epi)genetic changes, potentially causing FGR and childhood/adult diseases later in life.
To investigate te efficacy and the toxicity of protone radiation of thymomas and thymic carcinomas.
This study has been transitioned to CTIS with ID 2023-505284-36-00 check the CTIS register for the current data. Objective 1: To compare MK-7684A to pembrolizumab alone with respect to ORR in participants with cervical cancer whose tumors express PD…
A relatively new method to determine margin distance is intraoral resection with a small Ultrasound (US)-probe. US is already used to determine tumor-thickness in tongue cancer preoperatively, because of its high predictive value. Four previous…
This is a feasibility designed to investigate the feasibility of collecting QoL information from patients via digital tools. By feasibility, we mean the assessment of the uptake of the tool, the compliance to schedule and the quality of the data…
Primary Objectives1) To compare the Progression Free Survival (PFS) per RECIST 1.1 as assessed by blinded independent central review (BICR) in first line recurrent / metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) subjects, treated…
To determine the prevalence of taste and smell dysfunction in patients more than two years after start of ICI therapy - compared with a control group of caregivers. Secondary objective: to assess the association between taste and smell dysfunction,…
This study has been transitioned to CTIS with ID 2023-508723-12-00 check the CTIS register for the current data. Primary Objective• To assess superiority of treatment with CAM2029 compared to treatment with octreotide long-acting release (LAR) or…
Primary objective: To assess the effect of ICI on progression of coronary non-calcified plaque volume and ICI-related cardiovascular events by measuring differences in plaque burden using repeated CCTA.Secondary objectives:- To evaluate the relation…
This study has been transitioned to CTIS with ID 2024-518931-12-00 check the CTIS register for the current data. Primary:- To test whether bevacizumab added to a backbone chemotherapy regimen (temozolomide or irinotecan-temozolomide or topotecan-…
This study aims to investigate whether the administration of VCR in children with acute lymphoblastic leukemia, nephroblastoma, low-grade glioma, Hodgkin lymphoma and rhabdomyosarcoma by one-hour infusions, resulting in lower peak plasma…