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Detection of Mast cells in Systemic Mastocytosis

We here wish to apply new advancements in multi-color flow cytometry for a detailed and sensitive examination of mast cells in peripheral blood of patients with SM.

investigation of the relation between trombo-embolic events and microparticles in essential thrombocythemia and polycythemia vera patients

To determine the levels, cellular origin and procoagulant function of microparticles in ET and PV, and to explore the existence of a correlation with jak2V617F mutation, medication and vascular events.

Platelet analysis in patients with haematological diseases with increased risk of thrombosis and bleeding

To better treat and understand bleeding and thrombotic complications of these diseases and treatments, more insight is needed into the pathophysiology. WIth the findings of the current study we would like to increase knowledge on how platelets (and…

Mast cells and fibrosis in myeloproliferative neoplasms.

The primary objective is to investigate the role of the hematopoeitic niche and mast cells in the bone marrow of MPN, and the effect of pharmacotherapy on these cells.

Molecular phenotyping of Mast Cells in Indolent Systemic Mastocytosis using Single Cell RNA-sequencing

To investigate which molecular mast cell phenotypes (as defined by the expressed genes and gene-networks) in bone marrow resident mast cells and their progenitors are associated with the presence or absence of ISM.

Immunological analyses of Long-term Molecular and Cellular Responses to Hymenoptera Venom Immunotherapy Indolent Systemic Mastocytosis patients.

The primary objective is to assess the adaptive T cell response to VIT in HVA patients with underlying ISM (ISM+) after treatment induction (at thirteen weeks) and upon reaching maintenance dose, after seven months, in comparison to the baseline…