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Creatine kinase, platelet aggregation, and bleeding risk in women with uterine leiomyomas

Main study:We want to assess whether bleeding risk in women with uterine leiomyomas is associated with CK activity and attenuated platelet aggregation.Objective of pilot study:Firstly, to perform a feasibility pilot of CK/AK measurement in menstrual…

Levonorgestrel spiraal versus progesteron oraal voor de behandeling van hyperplasie zonder atypie van het endometrium.

Treatment of endometrial hyperplasia by an IUD that contains progesteron is more effective and has less side-effects than the treatment with progesteron oral.

Procedural sedation for hysteroscopic myomectomy: cost effectiveness

Is hysteroscopic resection of submucous myomas under procedural sedation with propofol (PSA) in an outpatient setting a cost-effective alternative for hysteroscopic myomectomy performed under general anesthesia in the operation room?

SAFE: Sequre for Adenomyosis and Fibroid Embolisation

The aim of this research is to test the efficacy and safety of a new microcatheter 2.8F Sequre for treatment of uterine fibroids and/or adenomyosis with a standard embolization technique and to demonstrate the added value of this catheter, namely to…

Ulipristal versus standard surgical treatment in symptomatic uterine fibroids

This study has been transitioned to CTIS with ID 2024-512602-26-00 check the CTIS register for the current data. Evaluate the (cost-) effectiveness of ulipristal in comparison with standard surgical treatment for symptomatic uterine fibroids,…

Uterine artery embolization versus hysterectomy for symptomatic adenomyosis: a case-control study

This study aims to evaluate the impact of UAE on Quality of life (QOL) in comparison to hysterectomy in adenomyosis patients. A cost-effectiveness study will be part of the trial as well as a cohort hysterectomy group to clearify imaging and…

Discovery of biomarkers in cervical smears for diagnosis and prognosis of cervical lesions

To identify molecular biomarker profiles that are associated with cervical tumorigenesis, and that can be used for development of an algorithm for detection of low grade CIN1, CIN2, CIN3 and cervical cancer. The algorithm should provide advice for a…

Visualizing uterine microvasculature using contrast-enhanced ultrasound for differentiating between uteri with adenomyosis, myoma, sarcoma, and no uterine disorders

Primary objective:1) To determine the discriminating ability of the microvasculature between uteri with adenomyosis, myomas and no uterine disorders. Secondary Objectives: 2) To determine the discriminating ability of the microvasculature between…

TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia, a multicenter, open-label, non-randomized, controlled study (TOPIC-3 study)

This study aims to investigate the treatment efficacy, side-effects and quality of life associated with imiquimod treatment of high-grade CIN lesions in a selected population of patients who prefer imiquimod treatment instead of LLETZ. The study…