Search for a trial

A Randomized, Comparative Trial of Two Posterior Lamellar Keratoplasty Techniques.
Ultrathin Descemet Stripping Automated Endothelial Keratoplasty (UTDSAEK) versus Descemet Membrane Endothelial Keratoplasty (DMEK).

To demonstrate that DMEK is superior to DSAEK with respect to VA.

New diagnostic tests in autonomic failure to improve diagnosis for PAF and MSA patients.

Primary: To explore the diagnostic value to distinguish PAF and MSA of a variety of tests: corneal confocal microscopy optical coherence tomography (OCT) to measure the retinal nerve fibre layer thickness and total macular volume, corneal…

Safety and Efficacy of Abicipar Pegol (AGN-150998) in Patients With Neovascular Age-related Macular Degeneration

To evaluate the safety and efficacy of abicipar (2 mg), compared to 0.5 mg ranibizumab in treatment-naïve patients with neovascular AMD.

Standard versus transepithelial corneal crosslinking for treatment of progressive keratoconus

To evaluate the role of the epithelium in the effect of CXL for treatment of progressive KC and to determine whether the epithelium should be removed or can be left intact during treatment.

A 24-month, phase IIIb, randomized, double-masked, multicenter study assessing the efficacy and safety of two treatment regimens of 0.5 mg ranibizumab intravitreal injections guided by functional and/or anatomical criteria, in patients with neovascular age-related macular degeneration (CRFB002A2405, OCTAVE study)

Primary: to evaluate the effectiveness of two treatment regimens by assessing the average stable maximum best-corrected (BCVA) change from Month 4 to Month 12 compared to Month 3. A treatment regimen will be considered a relevant treatment option if…

A randomized, double masked, active controlled, phase 3 study of the efficacy, safety, and tolerability of repeated doses of intravitrial VEGF Trap-Eye in subjects with neovascular age-related macular degeneration (AMD)

Primary objectiveTo assess the efficacy of intravitreally (ITV) administered VEGF Trap-Eye compared to ranibizumab (in a non-inferiority paradigm) in preventing moderate vision loss in subjects with all subtypes of neovascular AMD Secondary…

Genetic background of age-related macular degeneration in the North-Limburg region

To investigate if there is an association with the R142W mutation in the RDS gene in a group of dry AMD patients from the North Limburg region

Straylight as a possible parameter for a Functional Classification System of Posterior Capsule Opacification (FCSPCO) and glare complaints.

- Development of FCSPCO.- Determine if straylight is a reliable parameter for FCSPCO.

A Randomized, Comparative Trial of Two *Mushroom* Keratoplasty Techniques in Keratoconus Patients. Femtosecond Laser Aided True Mushroom Keratoplasy versus Microkeratome Assisted Lamellar Keratoplasty (MALK).

To demonstrate that FS laser aided keratoplasty for KC is superior to MALK.

Tear biomarkers for Alzheimer's disease (AD) screening and diagnosis

To investigate whether tear biomarkers can differentiate between patients and controls, and between patient groups.

A Phase 3, Multi-Center, Randomized, Double-Masked, Sham-Controlled Study to Compare the Efficacy and Safety of Intravitreal Pegcetacoplan Therapy with Sham Injections in Patients with Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)

Primary To evaluate the efficacy of Pegcetacoplan compared to sham injection in patients with GA secondary to AMD assessed by change in the total area of GA lesions from baseline as measured by FAF.Key SecondaryTo evaluate the efficacy of…

Microinterventional endocapsular nuclear fragmentation assisted cataract surgery versus conventional phacoemulsification using divide-and-conquer: a randomized controlled trial

To compare miLOOP assisted cataract surgery and conventional surgery with respect to the energy needed for phacoemulsification and loss of corneal endothelial cells.

Methylprednisolon Pulse Therapy vs Methylprednisolon Pulse Therapy combined with Radiotherapy for Moderately Severe and Active Graves* Orbitopathy

In this study, we want to demonstrate that MPP is no less effective than MPP plus XRT.

A Two-Year, Randomized, Double-Masked, Multicenter, Two-Arm Study Comparing the Efficacy and Safety of RTH258 6 mg Versus Aflibercept in Subjects with Neovascular Age-Related Macular Degeneration.

Primary:• To demonstrate that RTH258 6 mg is not inferior to aflibercept 2 mg with respect to the change in best-corrected visual acuity (BCVA) from Baseline to Week 48Secondary:• To demonstrate that RTH258 6 mg is not inferior to aflibercept 2 mg…