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Grumpy or depressed? Disentangling normative irritability from early signs of depression among adolescents with cell-phone micro-measures of daily mood swings.

Objective: We would like to differentiate *normative mood swings*. in adolescence from early signs of depression. A comparison between low-risk adolescents and an at risk and a clinically referred sample is needed to detect an unrecognized subsample…

Disrupting the rythm of depression: effectiveness and cost-effectiveness and mediating factors of preventive cognitive therapy, with or without antidepressants and compared to antidepressants alone, in the prevention of recurrent major depressive disorder.

The objective of this study is threefold:1) compare the effectiveness and cost-effectiveness of brief CT added to maintenance AD versus maintenance AD alone versus guided tapering or discontinuation of AD with brief CT.2) examine whether the…

Diagnostic Imaging of Affective Disorders using Emotion-processing in non-depressed patients
(DIADE-II).
A neuroimaging study to determine biomarkers to discriminate unipolar and bipolar depression

We aim to (1) improve differential diagnosis of recurrent MDD and BD by investigating biomarkers at a neuropsychological and neurobiological level ; (2) investigate whether affective neuropsychological testing can be used as a diagnosios tool for…

Attentional processes in depressed and non-depressed adolescents

1) To examine whether adolescents with depression, show abnormalities during specific attentional processes, compared to normal controls, 2) To determine whether abnormalities in attentional processes can be considered as prognostic markers of a…

Detection and treatment of major depression in patients with somatic illnesses admitted to the general hospital

The aim of the study is to:1. assess the prevalence of depression in patients with somatic illnesses admitted to the general hospital and to examine which self-report questionnaire is most suitable to screen for depression in this setting;2. to…

International Study for the Prediction of Optimized Treatment - in Depression

The overall objectives of the iSPOT-D trial are to use standardised genetic-brain-cognitionprotocols to:1. Identify markers of MDD as a diagnostic group and its subtypes2. Identify markers which change with acute (8 weeks) drug treatment in MDD3.…

Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in iRritable bowel syndrome In Europe

Primary Objective: The overarching goal of the multicentre trial is to characterize the overlap between mental and non-mental comorbid conditions of IBS. In IBS and patient control groups we will characterize depression, anxiety, fibromyalgia and…

STRENGTHS: Fostering responsive mental health systems in the Syrian refugee crisis

Primary Objective:To evaluate feasibility, acceptability, effectiveness and cost-effectiveness of the culturally adapted PM+ intervention forSyrian refugees in The Netherlands.Secondary Objective(s):1. To translate and (culturally) adapt PM+ for use…

D*Phase psychotherapy study - Research on counselling for depression
What works best for whom* and when?

1. To prove that Short-Term Psychodynamic Psychotherapy (STPP) is in fact non-inferior to Cognitive Behavioural Therapy (CBT) in the treatment of Major Depression so it can be considered a treatment of first choice in the Dutch Guidelines for…

Therap-i: A personalized monitoring and feedback tool as an add-on to support standard treatment for depression.

The main aim is to investigate efficacy of the Therap-i module, in addition to treatment-as-usual (TAU), in decreasing depressive symptoms in patients with MDD, who are unresponsive to protocolized psychological treatment for depression.