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Study to identify the genetic variations associated with phantom limb pain

The primary goals of this study are to: i. Identify genetic variations responsible for PLP across the whole genomeMore than 90% of SNPs are found in introns or intergenic regions and most of them are probably of little functional consequence.…

A pilot study on magnetic resonance imaging of the distal radial growth plate: defining healthy and pathologic characteristics in a non-invasive manner

1. The primary objective is to evaluate the characteristics of the distal radial growth plate on MRI (including functional imaging techniques) and on conventional radiographs in young gymnasts with wrist pain, compared to young gymnasts without…

What is the most optimal treatment strategy for an adolescent with knee complaints?

What is the most optimal treatment strategy for children / adolescents with knee complaints? Our hypothesis is (based on the invasive surgical procedure) patients that will be surgical treated (index group) have a clinical relevant gain of pain…

Randomized controlled trial comparing conVEntional RadioTherapy with stereotactIC body radiotherapy in patients with spinAL metastases

Our aim is to study whether the pain response after three months in patients with bone metastatic disease increases after SBRT in comparison to low dose EBRT.

Boneloss following immobilization in diabetes mellitus, an inventory using an ultrasound method (BINDEX).

The purpose of the study is to investigate the effect of (repeated) cast immobilization on the bone strength of the lower leg in patients with diabetes mellitus. In this study, bone strength is examined by cortex thickness in millimeters and density…

Osteoporosis and Activation Study of the Immune System in HIV

In this exploratory pilot study, we aim to investigate the role of immune activation in osteoporosis in HIV-infected patients on HAART with proven osteoporosis/ osteopenia in comparison to HIV-infected patients on HAART without osteoporosis/…

Bone density in apheresis donors compared with blood donors. A pilot-study.

To investigate whether bone mineral density is lower in apheresis donors than in blood donors.

Neurogenic inflammation in diabetic polyneuropathy and Charcot neuro-osteoarthropathy: response to intracutaneous Candida albicans

To study the inflammatory response (induration) to intracutaneous Candida albicans in healthy individuals, patients with diabetes without polyneuropathy, patients with diabetic polyneuropathy and patients with a history of Charcot neuro-…

The contribution of the sympathetic nervous system to the anabolic effect of estrogen on bone.

The objective is to study the effect of beta-agonist and beta-antagonist treatment on human bone remodeling.

Monitoring bone defects of the femur before hip revision and bone growth after hip revision arthroplasty with DEXA, a pilot study

Is DEXA accurate to predict bone loss of the femur before undergoing hip revision arthroplasty and provide a tool for quantification of bone loss of the femur before hip revision arthroplasty? Can DEXA be used to monitor bone remodelling after hip…

A multicenter randomised study in which operative stabilization of rib fractures with a flail chest is compared with mechanical ventilation.

The Purpose of this study is to compare the surgical treatment of flail chest with the non-operative treatment regarding complications.Hypothesis: Surgical stabilization of rib fractures in flail chest results in fewer respiratory complications,…

Distal renal tubular acidosis in Sjögren Syndrome and postmenopausal osteoporosis

The aims of the present study are 1) to confirm the high prevalence of dRTA in Sjögren using the urinary acidification test with ammonium chloride, 2) to determine the prevalence of disorders in calcium metabolism in pSS patients with dRTA, 3) to…

Bone - MRI in Renal Insufficiency

The objective of this study is to assess the diagmostic accuracy of microMRI to detect ROD in children with ESRD and metabolic bone disease by oxalosis in patients suffering from oxalosis.

The cost of being stable: Does the effort for balance control affect the energy cost of walking in amputees and stroke patients?

The objective of this study is to investigate whether impaired balance control is (partly) responsible for the increased energy cost of walking in stroke patients and amputees by evaluating the effect of external stabilization and destabilization on…

Chevron osteotomy for the treatment of hallux valgus - Effectiveness of postoperative immobilisation by a plaster cast or walking boot

Primary aim of the study: to compare the preservation of the correction of hallux valgus angle by means of a Chevron osteotomy with postoperative immobilisation by means of a plaster cast or a removable walking boot, one year following surgery.…

Cervical spine movement, before and after anterior cervical discectomy (ACD).
ACD, pure intervertebral discectomy (1) compared to intervertebral discectomy followed by implantation of an intervertebral disc prosthesis (2) in patients with a radicular syndrome. A randomised study

Objective of the study is to verify whether the movement pattern after anterior cervical discectomy normalises, in case of implantation of a cervical disc prosthesis.

The Effect of Gaucher Disease on Bone Cells

This will be a pilot study that aims to gain insight into the effect of Gaucher disease on bone metabolism. For this purpose we formulated the following research questions:What is the effect of inflammatory factors in the serum of patients with…

Cost-effectiveness of nerve root decompression according to Gill versus instrumented fusion in the treatment of spondylolytic spondylolisthesis; a multicenter prospective randomised trial.

The Sciatica-Gill trial is a randomised cost-effective study about nerve root decompression according to Gill versus instrumented fusion in the treatment of patients with radicular legpain or neurogenic claudication due to spondylolytic…

A Feasibility Study on the use of Percutaneous Instrumentation for less invasive surgery of Scoliosis Deformity in Children with Neuromuscular Disease.

To test the surgical feasibility of the less invasive percutaneous pedicle screw instrumentation system for the treatment of children with a so called "hypotonic" scoliosis. Additionally, postoperative pain reduction and a reduced hospital…

Vertebroplasty versus radiotherapy as palliative treatment of vertebral metastases of multiple myeloma (M. Kahler)

Compare vertebroplasty with radiotherapy regarding costs and effectivity in treating pain, restoring mobility, and improving quality of life.