31 results
PRIMARY OBJECTIVE1. To determine the contractile strength and the (ultra)structure of single diaphragm muscle fibers of mechanically ventilated patientsSECONDARY OBJECTIVE1. To determine whether diaphragm muscle fiber weakness is part of a…
The primary objective is to study the course of muscle (fiber) atrophy in elderly males and females with a fall-related hip fracture or elective hip surgery and the influence of additional nutritional support during hospital admission. Secondary…
The objectives of this study are:1) to quantify the muscle symptoms, muscle complaints, limitations in daily living, fatigue, mood disorders, and quality of life in patients with Brody's syndrome.2) determining the genetic background of Brody…
PRIMARY OBJECTIVE:To determine the contractile strength of diaphragm fibers of COPD patients before and after in vitro exposure to CK-107. SECONDARY OBJECTIVE:To determine the contractile strength of latissimus dorsi fibers of COPD patients before…
1) Determine the sarcomeric function in muscle fibers from FSHD patients2) Determine whether sarcomeric dysfunction is specific for FSHD or is part of a generalized pathology common to muscular dystrophies3) Test new therapeutic strategies (in vitro…
To fully characterize skeletal muscle strength and endurance, phenotype and muscle fiber type-specific satellite cell content in frail elderly as compared to those elderly that do not classify as frail according to clinical criteria.
To investigate the effects of 5 days of one legged knee immobilization with or without daily NMES on quadriceps CSA, lean mass and muscle fiber characteristics.
The aim of this study is to develop an immortalised B-cell line derived from MG patients. This antibody producing cell line will be used for different applications:- The establishment of new passive transfer disease models for MG- The identification…
(A) Determine the influence of anger and frustration on self-reported bruxism.(B) Validation of a new ambulant electromyographic (EMG) diagnostic device for bruxism (TeleBrux).(C) Determine the additional value of peripheral modulation with…
The primary aim of this study is to identify the muscles that are most critical to the abnormal standing posture, standing balance and gait in FSHD patients and to elucidate the most important mechanisms of falls. The ultimate goals are (1) to…
The aim of this study is to identify direct markers of muscle and adipose tissue hypoxia in COPD and CHF patients in relation to the altered muscle oxidative phenotype and the putative mediators HIF-1α and PPARs/PGC-1. Insight in the underlying…
To investigate (1) whether basal levels of oxidative stress differs between COPD patients and healthy volunteers and (2) whether exercise-induced oxidative stress after a single-leg ergometer test differs between patients and healthy controls (3) to…
We aim at investigating the role played by the innate and adaptive immune system and orienting a proper treatment. We will evaluate the percentage and features of circulating activated immune cells and cytokine production. As a second step, we will…
Primary Objective: To investigate whether differences exist in muscle function, muscle energy metabolism and cardiorespiratory fitness in CML patients with muscle complaints, compared to CML patients without muscle complaints, and controls (non-CML…
We aim at investigating the interplay between DUX4 and inflammation in FSHD combining MRI imaging, histology, gene and cytokine expression.
This study aims to isolate and culture myogenic stem cells called mesoangioblasts from the muscle biopsies to explore if genetic correction of LAMA2 mutations using CRISPR-Cas9 can be achieved and subsequently assess the effect in vitro, as a first…
Primary objective: To investigate the prevalence of bruxism and TMD in PD patients through objective measurements and to identify factors associated with a higher risk of developing these symptoms.Secondary objectives: - To investigate the salivary…
The first aim of this study is to use an in vitro approach using patient*s derived material to accurately and rapidly predict the optimal therapeutic approach that will predict a good clinical response in individual patients. The second aim of this…
Objective1) Validate the biomarker potential of CXCL10, TNFR2, and galectin-9 in disease activity monitoring of JDM and DM.2) Determine the role of IL-18, CCL2, CCL4, CCL19, CCL27, CXCL10, CXCL13, TNFR1, TNFR2, galectin-9 and other potential…
The primary objective is to identify clinical and biological measures that discriminate paediatric ME/CFS and post-COVID patients from healthy controls based on either clinical (based on physiological tests and questionnaires) and biological (based…