258 results
To investigate the effectiveness and safety of the RT-CGMS in patients treated with intraperitoneal continuous insulin infusion (CIPII).
The present study will investigate vaginal blood flow, measured by vaginal photoplethysmography, in pre- and post-menopausal women affected with DM type 1, and in an age and menopausal status matched sexually functional control group. Changes in…
We hypothesize that membrane-residing gangliosides are elevated in obese insulin resistant subjects and correlate to peripheral insulin resistance. Furthermore, we hypothesize that the perturbation of the insulin signaling cascade by elevated muscle…
Objective: We aim to assess whether [1] epigenetic alterations are responsible for the detrimental effects of maternal undernutrition during gestation on the offspring*s (F1) cardiovascular health, and [2] these epigenetic alterations pass down…
Does bilateral deep brain stimulation of the subthalamic nucleus in patients with Parkinson's disease influence plasma triglycerides and glucose metabolism?
The primary objective of this study is to investigate the peri-operative accuracy and safety of the RT-CGMS in cardiac surgical patients.The secondary objective is to identify and define possible factors interfering with reliable and adequate…
In this study, the effects of low-fat dairy products on metabolic risk markers in subjects at increased risk of metabolic disorders are determined.
The presently proposed study aims to investigate the effects of different dairy products, which are frequently used in the Netherlands and not yet analyzed, on Glycemic Index and Insulin Index in humans. This will be investigated by analyzing…
- To systematically determine metabolic adverse affects of RA patients, who (chronically) use GCs in order to reduce disease activity, compared to RA patients who don*t use GCs.- To study the relation between disease activity, treatment, and…
1)To determine whether subjects at ultra high risk to develop schizophrenia display hepatic insulin resistance as compared to healthy controls matched for age, sex, BMI, ethnicity, visceral and subcutaneous fat mass.2)To determine whether…
Objective:1. To determine intra-individual variations of post absorptive glucose metabolism in patients with DM1 and healthy individuals.2. To determine the effect of short sleep deprivation on glucoregulation in patients with DM1 and healthy…
1. The primary aim of the study is to investigate whether periodontal treatment results in a decrease of plasma biomarkers that are related to cardiovascular diseases (CVD) and metabolic syndrome (MS) and what is the effect of the treatment on the…
To examine the effects of odors and / or visual stimuli of food in subjects after 56h of starvation on:-Endocrine parameters-Metabolic parameters-Anthropometric parameters-Autonomic nervous system parameters-Hypothalamic function
This study-protocol is directed at the comparison of two accepted management strategies at both ends of the current treatment-spectrum of moderate hypoglycemia in 'high risk' newborns: an intensive treatment versus an expectant monitoring…
To investigate the association between two polymorphisms of the HTR2C gene (5-HT2c-receptor gene) (3813929 C/T and rs1414334: C>G) and metabolic adverse drug reactions in starters with mirtazapine (5-HT2C-receptor antagonist) versus…
Aim of this study is to address the role of pancreatic ABCA1 dysfunction in humans. We hypothesize that beta cell capacity (insulin production) is reduced in subjects with loss-of-function-mutations in ABCA1.
The study objective is the assessment of influence on glucose homeostasis as a consequence of starting switching, discontinuing or doses changes with antidepressants in a population of diabetic patients.
The primary objective of this study is to demonstrate the impact on time in hypoglycaemia (number of hours per day of hypoglycaemic excursions < 3.9 mmol/L, 70 mg/dL) using the Abbott Sensor Based Glucose Monitoring System compared to Self…
High-field (7T) MRI and genetic biomarkers for neurocognitive impairment in type 2 diabetes melltius
The primary objectives: 1. To tailor and apply high-field multi-parametric and functional MRI techniques to identify cerebral biomarkers in DM2 and MetS patients compared to control subjects.2. To examine a specific set of genetic hypotheses in DM2…
To investigate whether the administration of Glucerna achieves less glycaemic variability, defined as the mean absolute glucose (MAG) change, and greater glycaemic control compared to a standard high-carbohydrate enteral formula. Continuous glucose…