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A phase IIIb, open, multi-centre gynaecological extension study for the follow-up of a subset of HPV-015 study subjects

To provide clinical management and, if required, treatment to subjects who at their concluding HPV-015 study visit displayed normal cervical cytology but tested positive for oncogenic HPV infection or who were pregnant at their concluding visit of…

A phase III, double-blind, randomized, controlled study to evaluate the safety, immunogenicity and efficacy of GlaxoSmithKline Biologicals* HPV 16/18 L1/AS04 vaccine administered intramuscularly according to a three-dose schedule (0, 1, 6 month) in healthy adult female subjects aged 26 years and above.

* To demonstrate efficacy of the candidate vaccine in the prevention of (1) persistent infection (6-month definition) with HPV-16 or HPV-18 (by polymerase chain reaction [PCR]) and/or (2) histopathologically-confirmed CIN1+ associated with HPV-16 or…

Prevalence of testicular microlithiasis in patients with Down syndrome

Determining the prevalence of testicular microlithiasis in Down syndrome.

Prevention of multiple pregnancies in couples with unexplained or mild male subfertility.

1. To prevent multiple pregnancies and the concomittant neonatal mortality and morbidity while retaining acceptable delivery rates in couples with unexplained subfertility or mild male subfertility and poor fertility prospects. 2. To assess the…

TePA-study (Tertiary Prevention of morbus Asherman-study);Evaluation of placement of hyaluronic acid (hyalobarier ® Gel Endo) and placement of a intrauterine device without cu or hormones to maintain separation of the cavity and mechanically to prevent spontaneous recurrence of adhesions.

Does the installation hyaluronic acid (hyalobarier ® Gel Endo), in patients with M. Asherman reduces or prevents the incidence and severity (ESGE score/classification) of spontaneous recurrence of adhesion better then the IUD without Cu or hormones…

MYPP-trial: Myo-inositol Supplementation to Prevent Pregnancy Complications in Women with Polycystic Ovary Syndrome: a multicentre double-blind randomised controlled trial

The primary objective of this study is to assess the effectiveness of myo-inositol supplementation to prevent pregnancy complications in women with PCOS. Secondary objectives are to evaluate the impact of supplementation on maternal (mental) and…

THE VULVA STUDY: Online psychotherapy and TENS@HOME for patients with provoked vulvodynia.

Overall we aim for a more effective treatment of provoked vulvodynia with less relapse, taking into account the patients autonomy as an important key to long term cure. Primary outcome: Decrease of pain during (attempt to) penetration, measured by a…

TUbectomy with delayed oophorectomy as alternative for risk-reducing salpingo-oophorectomy in BrcA-Women to assess the Safety of Prevention: the TUBA-WISP II study

To evaluate RRS with delayed RRO as an alternative for RRSO in BRCA1/2 gene germline mutation carriers. We hypothesize that RRS with delayed RRO leads to an equal ovarian cancer incidence when compared to RRSO.

Early TUbectomy with delayed oophorectomy to improve quality of life as alternative for risk reducing salpingo-oophorectomy in BRCA1/2 gene mutation carriers

To evaluate RRS after childbearing with delayed RRO as an alternative for RRSO in BRCA1/2 gene germline mutation carriers. We hypothesize that delay of menopause leads to an improvement of quality of life and sexual functioning, and a decrease in…

Follow-up study of subjects who participated in the IUGR-1, IUGR-2 and PROGRAM/PREMS study during childhood and early adulthood - Long term effects of growth hormone many years after discontinuation

To evaluate the long-term effects of GH-therapy on metabolic profile and risk factors for cardiovascular diseases in adults (aged 25-35 years) born SGA and compare this with non-treated adults born SGA and with adults born AGA.