819 results
The objective of this study is to test the hypothesis that in patients with inflammatory neuropathies and conduction blocks, corticosteroid treatment leads to:1. Hyperpolarization and reduced excitability of motor axons. 2. An increase of the number…
The purpose of this study is to gain insight into the effects of auditory pacing on the stability and flexibility of hemiplegic gait coordination. It will be examined how auditory pacing can be best administered to improve the quality of hemiplegic…
To investigate whether exposure to nanoparticles is able to induce short-term functional changes in the brain, we previously exposed human volunteers for one hour to diesel exhaust particulates (300 ug/m3) and followed their brain activity during…
Primary: To determine whether medical management improves long-term outcomes of patients with unruptured BAVMs compared to invasive therapy (with endovascular procedures, neurosurgery, or radiotherapy, alone or in ombination). The trial has been…
The main research question of this study is:Is client-centred occupational therapy according to the Occupational Performance Process Model more effective than usual-care occuaptional therapy in patients with multiple sclerosis?
To assess whether there is less peri-operative pain and a faster post operative recovery.
Can mitochondrial dysfunction (especially reduced complex I activity) be observed in skeletal muscle samples from patients with autosomal recessive PD (in this pilot study, parkin parkinsonism)?The project is expected to (a) clarify the possible…
Aim of the study is to investigate what the influence is of insomnia on driving performance and to what extent this influence is attenuated by the use of hypnotics. Therefore, over-the-road driving performance of treated and untreated patients…
This study aims at investigating in vivo the macroscopic and microscopic aspects of brain and cervical cord neuroaxonal pathology in multiple sclerosis in a cohort of PPMS patients, by measuring brain and cervical cord atrophy, the ratio of N-…
The primary objective of this study is to identify the brain changes following peripheral nerve injury and establishing their functional role in recovery. The secondary objective is to evaluate new fMRI methodology in a patient population.
Track-HD is designed to relate phenotypic characteristics in as many modalities as can be measured (clinical, cognitive, quantitative motor, oculomotor, neuropsychiatric, imaging, laboratory) and genetic factors, in order to relate phenotypic…
The present study aims at exploring a visuo-tactile mirroring mechanism in patients with autism. Furthermore, the relationship between neural tactile simulation processes, empathic abilities, and symptom severity in the social domain will be…
The objective of the study is to explore the effects of EMG-triggered multi-channel electrostimulation on motor function of the arm after stroke.
1)To determine the contribution of reversible dysfunction of nerve terminals to weakness 2) To identify electrophysiological patterns that improve classification of GBS patients, and that discriminate between patients with good and poor prognosis 3…
Primary:1. Which outcome variables of oculomotor performance and eye-hand coordinatio are useful to distinguish between Dementia with Lewy bodies, Alzheimerdementia and Parkinsondementia.Secundary:1. What are the base line values for the parameters…
Objectives: To optimize SSEP recording methods to improve diagnostic procedures in myoclonic disorders. More precisely, to determine whether enhanced N35 potentials are more commonly found using multichannel (64 channels) SSEP versus conventional (5…
The primary aim of this study is to evaluate the added value of hemodynamics for multi-factorial rupture risk assessment of intracranial aneurysms. The secondary aim is to build a statistical model that can best predict aneurysm rupture taking into…
The current study assesses activation of hippocampus and prefrontal cortex during sleep spindles in veterans with and without PTSD. Furthermore, the correlation between sleep spindles and memory consolidation will be examined.
The question, however, remains whether there are changes in pain processing in chronic RSI and whether the general process of pain sensitization is comparable to that seen in CPRS. In animal research (Byl, 1997) it has been shown that after…
Objective of the study is to investigate the effects of aspirin on the platelet function of healthy volunteers and of patients with ischemic stroke. In another part of the study, we will investigate whether or not the effects of aspirin on the…