819 results
Objectives- To study presence of (Cortical) Spreading Depression ((C)SD), using direct current (DC) EEG changes in migraine patients during different phases of the migraine attack;- Is there a change in DC-EEG recordings suggestive of (C)SD,…
To visualize the affected nerve roots using DTI with tractography. The anatomy and organisation of the nerves on the level of the lumbar disc herniation will be visualized. Diffusion parameters as FA, ADC, AD, and RD could provide valuable…
How important is fatigue in patients with MTBI? What are the mechanisms underlying the decline in force during a fatiguing task? Which changes in brain activation take place during the fatiguing task?
The aim of the proposed research is twofold: 1) To investigate whether TMS can help guide individual AED treatment to improve response. a. in people with first seizures b. in people who (temporarely) want to lower or stop medication2) To investigate…
The primary objective is:1. To investigate whether high frequency low dosage IVIg treatment is more effective than low frequency high dosage as maintenance treatment for CIDP. Secondary objectives are:2. To investigate whether high frequency low…
To compare functional recovery of the patient and the fusion status of ceramic cages versus PEEK cages on the short and long term.
The aim of this *proof-of-principle* study is to demonstrate that 18F-florbetaben PET can detect amyloid deposition in the myocardium in patients with proven cardiac amyloidosis and excluded amyloid deposition in the myocardium of healthy subjects.…
To assess whether treatment with DBS can reduce or resolve TDD and if DBS can induce beneficial or side effects in particular psychiatric and or cognitive symptoms.
The aim of the present study is to investigate the reproducibility of upper extremity strength measurements in children with CP. The following strength measurement instruments will be studied: Hand Held Dynamometry (HHD), pinch- and grip strength…
The primary objective is to measure the availability of the PDE10A enzyme in Huntington*s Disease (HD)gene expansion carriers (HDGECs) by estimating and comparing the distribution volume (VT) of the radioligand [18F]MNI-659 in the striatum (caudate…
1. Study the BBB permeability in cSVD patients and compare it with healthy control subjects. 2. Examine the relationship between BBB permeability and cognitive function. 3. Examine the relationship between BBB permeability and the extent of…
The goal is to find answer to the question: do epidural injections with corticosteroids in patients with sciatica have a positive effect on pain, absenteeism from work and number of operations compared to standard care (pain medication only).
Our objective is to obtain insight into whether and how the visual and auditory systems of hemispherectomized patients have adapted after brain damage and brain surgery in early life. For this purpose we will perform psychophysical tests and (…
We purpose to determine whether the international normative values are applicable in our center in 10 healthy participants. Furthermore, CCM will be introduced as additional diagnostic tool in patients with (possible) SFN.
Cognition in patients with Juvenile Myoclonus Epilepsy and their first degree healthy family members
Key Question: What is the level of cognitive performance in healthy siblings of juvenile myoclonic epilepsy patients compared to that of patients with juvenile myoclonic epilepsy?
Primary objective is to study the number of patients gaining at least 50% pain reduction within 8 weeks following PRF as compared to following a neurectomy. Pain intensity will be measured using numeric pain rating score (NPRS, 0-10) and Verbal…
Primary objectives1) To clarify which components of spatial remapping are impaired after damage to the posterior parietal cortex.2) To correlate spatial remapping abilities with scanpath quality in visual search.3) To examine whether different…
We aim to to record heart rate patterns during seizures with miniaturized wearable EKG-monitors in a large cohort of DS
Primary Objectives:Part 1:To assess the relative bioavailability and bioequivalence of JZP-258 compared with Xyrem oral solution under fasting and fed conditions.To evaluate the pharmacokinetics (PK) of JZP-258 under fasting and fed conditions (food…
Primary objective of this study is to investigate whether EEG can be used to predict future febrile or afebrile convulsions. Secondary objectives of this study are to investigate the influence of EEG on antiepileptic drug prescription (will…