114 results
The main objective of this study is to evaluate the differences in [18F]FEOBV binding between PD patients and healthy control subjects, in order to evaluate the clinical feasibility of [18F]FEOBV as a cholinergic imaging ligand in PD. Secondary…
The primary objective is to measure the longitudinal changes of PDE10A enzyme availability in the caudate, putamen, and globus pallidus of Huntington*s Disease Gene Expansion Carrier (HDGECs) by comparison of the follow-up and initial Positron…
Primary objectives:- To investigate possible differences in driving performances between premanifest gene carriers, manifest HD, and control subjects.- To explore if different aspects of cognitive functioning might be a predictor of fitness to drive…
The main goal of the study is to evaluate the feasibility of using 1) passive treadmill belt speed perturbations to measure spinal reflex activity in the calf muscles; and 2) active real-time visual feedback on dedicated gait parameters to highlight…
The primary objective is to assess the structural and functional segregation of the STN into its motor and non-motor regions in PD patients and healthy controls.The secondary objectives are:1. To compare the strength of the functional and structural…
Primary objective of this study is to assess the reliability, validity, and diagnostic value of the neuromechanical parameters of joint impedance estimated by nonlinear SIPE technology in patients with a spastic paresis.
To develop well-described protocols for three tasks, i.e. a grasping task based on movement imagery, a button-press task, and a somatosensory finger mapping task, to be used in a larger ensuing clinical study by stroke patients in the 7T-MRI scanner…
This project aims to determine the validity of a home-based continuous bradykinesia assessment using free typing behaviour analysis. Secondarily, we aim to capture the presence of sequence effect in Parkinson's Disease patients using a computer…
To assess the potential of the PET-tracer [11C]SMW139 to investigate the role of P2X7R, a cell surface receptor upregulated in activated microglia, in neuroinflammation in PD. The aim is to find the optimal tracer kinetic model which can be used to…
The aims of this study are the ascertainment, characterization, and longitudinal follow-up of a large cohort of Dutch families segregating Parkinson*s disease, including affected and unaffected first-degree relatives. The cohort will be…
Our aim is to investigate whether patients who are informed by video will have less preoperative anxiety than the patients who receive usual information.
2. OBJECTIVESPrimary Objective: 1. Does conversion tremor show similar abnormal cerebral activation patterns compared to conversion pareses?Secondary Objective:1. Is decreased precuneus activity also present in conversion tremor?
-To confirm the potential of a diagnostic tool to discriminate dystonic from non-dystonic muscles in CD patients-To explore the potential to discriminate CD patients from Functional Torticollis (FT) patients
Our primary objective is to identify the brain networks involved in tremor generation in homogeneous groups of ET patients. In addition we will investigate the differences on a behavioral level during goal-directed movements between ET subgroups and…
This project aims to understand the symptomatology PD in the light of functional brain interactions, in the hope of elucidating the role of the frontal striatal system to behaviour.
The main objective of this study is to develop a method to identify susceptible pathways of redox metabolism and bioenergetics in peripheral blood cells and induced pluripotent stem cells from patients with PD and DLB.
To investigate the differences in driving performance and safety between CD patients and healthy controls in a driving simulator. To compare the subjective evaluation of the difficulty of various aspects of the driving task driving in CD patients…
The main objective of this study is to characterize the features and the extent of extracerebellar structural pathology in SCA3 and SCA6 patients. Secondary objectives are:- To explore the sensitivity of DWI and other imaging modalities in detecting…
The project aim is to optimize existing EEG methods for recording and analyzing EEG data acquired during walking in combination with advanced VR methods for the investigation and rehabilitation of gait and balance impairments. The project aims to…
1. We will recruit 6 probands who experience cerebellar movement disorders with spinocerebellar ataxia features such as uncoordinated movement (i.e. asthenia, asynergy, delayed reaction time and dyschronometria) in limbs and organs such as the eyes…