143 results
Registry is the core study of the European Huntington*s disease Network (EHDN). The aim of the Registry study is to collect prospective data on the phenotypical characteristics of Huntington's disease (HD) mutation carriers regardless of…
to find evidence for frontal inhibition during planning of explicit movements just as seen in patients with conversion disorders.
We expect to isolate system-level neural mechanisms that support compensation for gait and balance in patients with SCA3 following an intensive five-week training programme on a virtual reality treadmill. The goal of the project is to understand…
Primary Objective: 1. Test whether the flash lag illusion is decreased in PD and more specifically whether the decrease is associated with bradykinesia.Secondary Objective(s): 2. Quantify bradykinesia by means of motion sensors and validate this…
Our goal is to develop and validate a Movement Diagnostic System (MDS) to accurately locate specific CNS pathological changes in ET, PD-T and DYS, with the use of fMRI and scanner compatible EMG, accelerometry, video, and wrist perturbator.
The primary objective is to study the effects of 12 weeks of treadmill training with virtual reality on neural plasticity in comparison to the effects of treadmill training without virtual reality.Secondary objectives are to investigate the role of…
In recent years, we have identified a Dutch family and performed a large number of studies which have helped us gain insight into the disorder. (MEC protocols 02/223 and 03/140, Dissertation Van Rootselaar, 2006). We want to call on family members…
The objective of this study is to provide a reliable overview of the oral health of Parkinson's disease patients in the Netherlands.
The main goal of this study is to investigate the influence of STN DBS on the cognitive processes of reward processing and selective visual attention.
To assess in a pilot setting whether there are differences (including sensitivity and specificity) in pen motion, grip force patterns and muscle activity, derived using a newly developed system for handwriting monitoring, between A: patients with…
To obtain more fundamental insight in the disrupted sensorimotor integration in patients with Parkinson*s disease, especially with regard to the impact of visual stimuli on the cerebral systems involved in walking. This knowledge provides a basis…
There is at present a major focus on the role of the cerebellum in the pathophysiology of dystonia. It is speculated that the cerebellum is an hitherto overlooked yet fundamental part of the abnormal sensorimotor network that drives dystonia. This…
We will perform a study to describe the echogenicity of the substantia nigra, red nucleus and brainstem raphe in PD patients with and without RLS, RLS patients without PD and healthy controls. The echogenicity will be correlated with the the serum…
To investigate the influences of MVF on pain and motor function in CRPS related dystonia and to investigate the feasibility of an MVF intervention in patients with CRPS related dystonia and the suitability of several outcome measures to determine…
To investigate whether balance control is asymmetrical in PD patients. In addition, we want to investigate the relationship between asymmetrical balance control and stepping responses, fall history and freezing of gait.
This project has three separate but complementary research objectives. First, to find out whether there is indeed evidence of subclinical cerebellar dysfunction in these subjects, by specifically focusing on cerebellar motor learning. Second, to…
The first objective of this study is to assess whether emotional responsiveness in PD patients is different from that of matched healthy controls and whether emotional responsiveness in PD patients with apathy is different from that in PD patients…
There is a complex organization in the motor system that channels the spatiotemporal commands necessary for a writing task and surround inhibition is a physiological mechanism to focus this neural activity. Surround inhibition (SI) aids the…
We propose an instrumented approach, during which the ankle is rotated in a precise and controlled way using a robot manipulator. Using neuromuscular modelling, key neuromechanical parameters as viscosity, stiffness and reflexive torque can be…
*Evaluate our current measurement procedure (*UX analysis report*), that objectively and accurately records the 3D movement of the UX, in healthy children to establish norm values, normal variation and reproducibility in children*Test whether the UX…