143 results
Our main objective is to conduct a pilot study testing the applicability and face/external validity of the battery in a young-onset PD cohort, alongside age-matched healthy controls. We aim to gain deeper insights into the complex interrelationships…
The aim of this research project is to study a large a group of patients with tonic dystonia longitudinally, to accurately describe the phenotype, to investigate the potential underlying mechanisms and to identify possible causes and risk factors.
The aim of this study is to assess the safety and the potential efficacy of personalized Local Field Potential (LFP)-based adaptive Deep Brain Stimulation (aDBS), using the implantable pulse generator (IPG), «AlphaDBS» System, in Parkinson*s Disease…
To identify which speech control mechanisms in PD patients are impaired and to what extent by comparing PD patients in various stages of the disease and adult control speakers.
The primary objective of this study is to confirm early and subtle MRI changes in PD patients which distinguish them from the healthy population and to create a diagnostic tool for neurologists based on these differences. Secondary objectives are to…
Our primary objective is to compare neuroimaging markers on a 3T MRI-scan with the MRI-scans that were performed during TRACK-HD in 2008-2011. We will assess the following neuroimaging markers, starting with the most important marker: 1. Structural…
Primary Objective: Assess the effect of mental imagery with fMRI-neurofeedback-based upregulation of the putamen on motor symptoms of PD Secondary Objective(s): -Assess changes in whole brain activation patterns over the course of the NF training -…
To determine early and subtle MRI changes in premanifest and early manifest HD patients which distinguish them from the healthy population. This includes both structural/quantitative MRI data and MRI-signs of blood-brain barrier (BBB) breakdown. And…
The goal of this study is to examine the feasibility of a home-based VR intervention to improve upper limb functionality in patients with CP. Primary research question: 1. Is VR-based gaming a feasible method to provide a rehabilitation intervention…
Objective: To study the effectiveness of pelvic physical therapy and ES in patients with PD suffering from LUTS. Which are the most effective parameters for ES. Intervention: Intervention: 8 treatment sessions of 30 minutes pelvic physical therapy…
The aim of this study is to assess whether the effectiveness of STN DBS for the treatment of Parkinson motor symptoms using imaging-based DBS programming is non-inferior compared to DBS programming with the current standard practice of clinical…
The primary objective is to determine the diagnostic accuracy of the automated diagnostic software (mPDia, Heuron) using SMWI to distinguish neurodegenerative parkinsonism from patients with non-neurodegenerative parkinsonism compared with the final…
Primary Objective: For the primary objective, the following research question is answered: Does performing asleep thalamic DBS provide an equal reduction in tremor compared to awake thalamic DBS, measured by the Essential Tremor Rating Assessment…
To demonstrate that steered STN DBS is more effective than ring-mode DBS in reducing PD motor symptoms and to demonstrate that steered STN DBS has the potential to cause less stimulation-induces side-effects.
Primary objective: To evaluate the role of existing and novel quantitative biomarkers in understanding the heterogeneity in the Parkinson*s phenotype (i.e. rate of progression, cognitive and neuropsychiatric impairment and motor dysfunction) and…
To assess the efficacy and tolerability of HUTS with different angles, leading to optimal implementation strategies of HUTS to alleviate the impact of orthostatic hypotension and supine hypertension in PD
The main goal of this study is to test the feasibility of two different operant conditioning methods to decrease hyperreflexia of children with CP/SP/HSP, using real-time visual feedback.
The aim of the study is to investigate the effect of an intensive high frequent parental coaching intervention on communicative abilities in patients with AS. Patients with AS who receive standard care, will serve as controls. Parents/caretakers in…
Main objective: We propose a proof of concept study to apply noninvasive brain stimulation, specifically tACS, for the first time to adult CG patients with the aim to find stimulation protocols that improve their motor and language performance by…
Identifying the genotype-phenotype-imaging correlates in GBA mutation carriers with and without Parkinson*s disease using functional and structural magnetic resonance imaging (MRI).