To identify which speech control mechanisms in PD patients are impaired and to what extent by comparing PD patients in various stages of the disease and adult control speakers.
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter is the change in speech patterns (both acoustic and
articulatory) before, during and after an auditory feedback perturbation.
Secondary outcome
Secondary study parameters include the acoustic characteristics of vowel and
consonant production; tongue tremor detection; and coordination of
articulators.
Background summary
Parkinson*s disease (PD) is common neurodegenerative disease characterized by a
loss of dopaminergic cells in the substantia nigra. Besides common motor
symptoms, patients also often encounter speech problems (i.e., hypokinetic
dysarthria), with symptoms that include monopitch, monoloudness, reduced
loudness, speech rate acceleration, inappropriate pauses, slurred speech, and
imprecise articulation. These speech problems range from mild to severe, but
can severely impact the patients* daily lives.
Despite an increasing interest in parkinsonian speech, it remains unclear
whether the underlying problem originates in patients being unable to plan
their speech production or in them being unable to monitor the incoming sensory
(especially auditory and tactile) information. Furthermore, it is unclear how
disease progression changes the nature and severity of these problems. We aim
to study the underlying mechanisms of speech production is by using auditory
feedback perturbations. We expect that PD patients will show different
adaptation patterns compared to adult control speakers.
Study objective
To identify which speech control mechanisms in PD patients are impaired and to
what extent by comparing PD patients in various stages of the disease and adult
control speakers.
Study design
In order to decrease the burden on the participant, the study will take place
in two sessions. During the first session, articulation will be recorded with
an ultrasound tongue imaging (UTI) device, while during the second session,
articulation will be recorded with an electromagnetic articulography (EMA)
device. In both sessions, the participant will perform several speech tasks,
some under normal feedback conditions, others while the auditory feedback is
perturbed. The data from PD patients will be compared to data from adult
control speakers.
Study burden and risks
There are no known risks or benefits associated with participation in this
study.
Oude Kijk in 't Jatstraat 26
Groningen 9712EK
NL
Oude Kijk in 't Jatstraat 26
Groningen 9712EK
NL
Listed location countries
Age
Inclusion criteria
- 40 years or older
- native speaker of Dutch
Only for the PD group:
- diagnosed with idiopathic Parkinson's disease
Exclusion criteria
- a score of 2 or higher on part 1.1 (cognitive impairment) or part 1.2
(hallucinations and psychosis) of the MDS-UPDRS
- history of neurological or psychological disorders
- self-reported signs of depression
- self-reported severe swallowing problems
- stuttering or other pre-existing speech problems (not occurring as a result
of Parkinson's disease)
- non-removable metal on, in or close to the head (e.g., piercings, dental
braces, medical devices such as DBS electrodes)
- pacemaker
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL72589.042.21 |
| Other | NL9381 (Netherlands Trial Register) |