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ID
Source
Brief title
Health condition
Parkinson's disease
Sponsors and support
Intervention
Outcome measures
Primary outcome
To identify which speech control mechanisms in PD patients are impaired and to what extent by comparing PD patients in various stages of the disease to adult control speakers.
Secondary outcome
Acoustic and articulatory characteristics of speech production in PD.
Background summary
Despite doing it almost without effort, speaking is a highly complex task requiring precisely timed and linguistically-driven coordination of the lungs, vocal folds and speech articulators (e.g. lips, tongue). This process, speech motor control, relies on both feedforward (pre-planned movements based on stored movement representations drawn from past experiences) and feedback (monitoring sensory input relative to what is expected) control mechanisms. Research suggests that these mechanisms may be impaired in Parkinson’s disease (PD) patients. However, current findings have resulted from studies with small samples and heterogeneous PD groups.
The central aim of this project is to identify which speech control mechanisms in PD patients are impaired and to what extent by comparing PD patients in various stages of the disease and healthy adults. Specifically, we will investigate how participants cope with feedback perturbations in speech, by measuring both the resulting acoustic speech signal and the underlying speech motor articulation using electromagnetic articulography and ultrasound tongue imaging. To assess whether the potential impairments of the feedback and feedforward system are speech-specific or more general (as PD is a movement disorder), we will also conduct feedback perturbation experiments in non-speech motor movement tasks.
The innovative combination of these methods will enable us to identify whether and how impairments of speech planning and monitoring are related to the progression of PD. Furthermore, the extent to which PD patients cope with feedback perturbations compared to healthy adults may potentially serve as a diagnostic marker for the disease.
Study objective
We expect that Parkinson's disease patients will show an impairment in feedback and feedforward speech control mechanisms when compared to healthy age- and gender-matched control speakers.
Study design
Session 1, session 2 (taking place within a month of session 1)
Intervention
N. A.
Inclusion criteria
- 40 years or older
- Native speaker of Dutch
Only for the PD group:
- Diagnosed with idiopathic Parkinson’s disease (according to the UK Parkinson’s Disease Society Brian Bank Clinical Diagnostic Criteria)
Exclusion criteria
- A score of 2 or higher on part 1.1 (cognitive impairment) or part 1.2 (hallucinations and psychosis) of the MDS-UPDRS
- History of neurological or psychological disorders
- Self-reported signs of depression
- Self-reported severe swallowing problems
- Stuttering or other pre-existing speech and language problems (not occurring as a symptom of parkinsonian hypokinetic dysarthria)
- Non-removable metal on-, in- or close to the head (e.g., piercings, dental braces, medical devices such as deep brain stimulation electrodes)
- Having a pacemaker
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL9381 |
| CCMO | NL72589.042.21 |
| OMON | NL-OMON55196 |