41 results
PROUD is a multicentre prospective study, using clinical factors in combination with additional tests with the aim to clarify more about the aetiology and pathogenesis of MS.
To identify (clinical) features of MMN patients that predict a poor clinical disease course. Moge agressive IVIg regimen can be established is this subgroup to maintain functional status of the patient. To find domains in quality of life in MMN…
a) To study the relationship between ankle push off and walking-induced motor fatigability and the potential confounders of this relationship in persons with progressive MS and healthy controls. b) To assess the feasibility of a targeted, sequential…
The main objective of the proposed study is to investigate whether the disproportionally strong clinical effects of fingolimod in RRMS can be explained by enhanced functional brain adaptation and whether enhanced functional adaptation is sustained…
(1) to establish the neuropsychiatric and personality status (symptoms and impairments) (2) to assess the possible determinants of these symptoms and impairments and (3) to examine the impact of these symptoms and impairments on daily life…
To investigate the impact of high field 3T MRI on the diagnostic criteria in MS in a large multicenter study population using multiple vendor MRI systems.
The main objective of the study is to investigate whether the strong clinical effects of natalizumab in RRMS can be explained by enhanced functional adaptation mechanisms of the brain and whether enhanced functional reorganisation is sustained over…
The aim of this MRI study is to understand how neurodegeneration in MS (in vivo) is related to other facets of MS pathology, i.e. inflammatory (T2) lesions, black hole (T1) lesions, cortical lesions and damage of the normal appearing brain tissue.…
The primary objective of this study is to determine the prevalence and degree of impaired cerebral venous drainage in MS patients in comparison to healthy subjects.Secondly, we want to determine a possible relationship between the degree of impaired…
The main point of this study is to detect in a controlled fashion if there is a relationship between CCSVI and MS. We focus on 5 parameters indicative of CCSVI: 1-reflux in the internal jugular vein (IJV) or in the vertebral vein (VV), or both with…
Primary: Does immunomodulation brought about by interferon beta-1a (Rebif) enhance or prolong functional reorganization in subjects with RRMS?Secondary: Does interferon beta-1a (Rebif) also affects functional connectivity as measured by resting-…
The primary objective of this study is to evaluate the efficacy (clinical and MRI) of switching tonatalizumab compared to receiving interferon β1-a or glatiramer acetate.
The objectives of this study are to compare the safety and efficacy of 2 annual cycles of intravenous (IV) alemtuzumab to 3-times weekly subcutaneous (SC) interferon beta 1a (Rebif*) in patients with active relapsing-remitting multiple sclerosis (…
Isolation of skin fibroblasts from MS patients for reprogramming into induced pluripotent stem cells
In this study we aim to address the hypothesis that oligodendrocytes and oligodendrocyte precursor cells from MS patients exhibit epigenetically determined differences in protein expression profiles and functional behavior in comparison to those…
The aim of the proposed study is to get more insight into the role of the hippocampus and thalamus in cognitive impairment in MS patients. To achieve our goal, we propose to study the (abnormal) structure and function of the two structures with…
In the proposed experiments we intend to investigate both central and peripheral aspects of fatigue in MS patients using a combination of simultaneously applied techniques; twitch-superimposition, electromyographic (EMG) and force recordings and…
This study aims at investigating in vivo the macroscopic and microscopic aspects of brain and cervical cord neuroaxonal pathology in multiple sclerosis in a cohort of PPMS patients, by measuring brain and cervical cord atrophy, the ratio of N-…
The objective of this study is the visualisation of diffuse and focal lesion in the brain in Multiple Sclerosis on higher main magnetic fields. Images from 1.5 Tesla MR scanners will be compared with images acquired at 3 Tesla and images made on 3…
In this study we would like to investigate whether cerebral perfusie and cerebral metabolism can be influenced with pharmacological agents in patients with MS and in healthy control persons. Cerebral perfusion and cerebral metabolism wil be measured…
In our longitudinal study we would like to investigate whether measures of neuronal damage, glial damage and oxidative stress are correlated with the speed of progression of disability. We would also like to investigate whether these variables…