20 results
Primary objective:The following hypothesis will be tested:MuSSAP in infants 4-12 months of age with diagnosed unilateral cerebral damage, is a feasible protocol and results in an enhanced motor development as compared to Intensive Usual Care (Upper…
The primary objectives of this study are:* To evaluate tracer kinetic models for the purpose of quantifying specific binding of 18F-AV-1451 in cross sectional and longitudinal applications; and* To evaluate simplified methods for quantification of…
Are changes in cognitive functioning related to structural changes in the brain in patients with type 1 diabetes mellitus. How are these changes related to diabetic complications like duration of chronic hypoglycaemia, disease duration and presence…
The goal of the study is to enhance the participation in daily life of children with CP, by increasing their independent use of the upper limb performing daily life activities. By training the task oriented strength in daily life activities…
Primary objective: To evaluate whether there is a difference in all-cause mortality at 180 days or longer with a target temperature management at 33°C compared to a target temperature of 36°C, in patients unconscious after out-of-hospital OHCA.…
Primary Objective: 1) To charaterize microbleeds and microinfarcts at 7T, and compare their prevalence in people with and without diabetes, with or without cognitive impairmentSecondary Objective(s): 2) To assess the relevance of the lesions in the…
Primary Objective: 1) To compare the prevalence en number of microbleeds at 7T between older people with and without DM2, and to relate the lesions to cognitive performanceSecondary Objective(s): 1) To characterize cerebral microinfarcts at 7T and…
The development of an attractive child centred intervention based on the forced use perspective, to study the effects regarding the following question:Is a period of 6 weeks Forced Use of the more affected upper limb (I) for children with Cerebral…
To assess if the studied TCD variables of cerebral autoregulation and hemodynamics are abnormal during preeclampsia. And if so, to determine if these changes are large enough to have potential value to determine a threatening cerebral dysfunction in…
The main objective of the study is to acquire more insight in memory for emotional information in patients with Alzheimer*s Disease, compared to healthy elderly people. A second objective is to explore the effect of emotional content on working…
The aim of the present study is to investigate the reproducibility of upper extremity strength measurements in children with CP. The following strength measurement instruments will be studied: Hand Held Dynamometry (HHD), pinch- and grip strength…
In this study, we aim to improve survival to hospital discharge and costs/QALY in young patients with OHCA by decreasing the time in cardiac arrest by initiating ECPR on scene.
To 1) clinically validate the novel PET-tracer [18F]AV1451 for tau pathology as a diagnostic and prognostic marker in tauopathies, 2) to examine the (change in) (regional) binding of [18F]AV1451 across tauopathies, and the relationships between (…
The primary goal of NEwTON is to study the link between repetitive head injury and neurodegeneration, leading to cognitive, psychiatric and behavioral symptoms as found in CTE. We will collect a prospective cohort of patients at high risk of CTE,…
We designed the study to test the hypothesis that post-ischaemic hypothermia, when compared tonormothermia and early treatment of fever, decreases mortality and improves neurologic functionin unconscious adults after out-of-hospital cardiac arrest.…
1A) To implement a screening-protocol for HIV related co-morbidities and their risk factors, based on multidisciplinary expert consultation, in a large HIV outpatient clinic and among an HIV-uninfected control group.1B) To assess the prevalence and…
The primary objective of the MANTA-study is to investigate MEG-based network topology and 'activity dependent degeneration' as mechanisms in the stereotypical spread of tau pathology (18F-AV1451 retention) in preclinical and clinical…
The primary objective of this study is to determine whether targeted therapeutic mild hypercapnia (TTMH) improves neurological outcome at 6 months compared to standard care (targeted normocapnia) (TN).
The main objective of this exploratory study it to determine the effectiveness of a 5-week functional gait training on the C-mill to improve gait adaptability in children and adolescents with CP. t The intervention will also be evaluated on activity…
We aim to collect blood cells from 40 patients with monogenic epilepsy, with a preference for patients with a pathogenic variant in SCN1A, reprogram these cells into iPSCs and use these iPSCs for differentiation into neurons and neuronal organoids…