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*The reproducibility of the energy cost of walking test and the 6-minute walk test to assess the physical strain of walking in post-poliomyelitis syndrome patients'

1. To determine the reproducibility of the ECWT and the 6MWT to assess the physical strain of walking in patients with PPS and in healthy control subjects.2. To evaluate the one-year course of the physical strain of walking among patients with PPS…

Neuromuscular functions in patients with the chronic fatigue syndrome versus patients with Fibromyalgia Syndrome and healthy people.

To investigate whether the CVS patients show the muscle membrane disturbances, as the FMS patients do. That is, are there muscle conduction velocities disturbances in the CVS patients?

Shoulder load and daily activities compared between power assisted and manual wheelchair propulsion.

The primary objective is to compare forces and moments acting on the shoulder of manual wheelchair users during power assisted wheelchair propulsion and manual wheelchair propulsion and the perceived upper extremity load. The secondary objectives…

Muscle relaxation time as outcome measure for myotonia in patients with non-dystrophic myotonic syndromes (NDMs)

In this study we want to investigate if relaxation time (RT) measured by handgrip myometry and muscle- elastography is a reliable outcome measurement for the quantification of myotonia in NDM patients. Mean RT values en standard deviations of NDM…

Decoding words with 7 Tesla functional MRI

The overall goal of this study is to assess the detection and discrimination of individual silently or attempted spoken words from the brain area that represents articulation of speech.To address this goal, we defined three primary objectives:1) To…

Brain INvolvement in Dystrophinopathies: BIND: Deep functional phenotyping of Duchenne Muscular Dystrophy and Becker Muscular Dystrophy patients (WP5) Part 2

The primary objective of the second part of the study, which is the focus of this application, is to perform a comparative analysis of the cognitive profile and MRI outcomes of DMD/BMD patients.

Capturing key symptoms using smartphone recordings in patients with myasthenia gravis.

The main objective is to explore whether digital features of dysarthria, dysphonia, proximal arm fatigue and ptosis can differentiate between participants with and without MG.

Selective Control Assessment of the Lower Extremities to probe the increased metabolic cost of walking after Stroke

The main objective is to examine the relationship between energy cost and (1) hip extensor and knee extensor co-activation, (2) plantar flexor and hip extensor co-activation and (3) plantar flexor and knee extensor co-activation in able-bodied…

Upper extremity outcome measures in non-ambulant Duchenne muscular dystrophy patients

Primary objective:1. To study the relation between muscle FF and two major clinical endpoints in different phases of the disease in non-ambulant DMD patients. Secondary objectives:2. To explore the use of Microsoft Kinect and Leap Motion in relation…

MR Imaging in Spinal Muscular Atrophy (SMA) as a biomarker for disease progression

To investigate the feasibility and usefulness of various MR techniques as a quantitative biomarker for SMA severity and disease progression. Two different MR protocols will be used. The first to investigate muscle tissue in the upper leg of both SMA…

Modelling human neuromuscular responses to electro-mechanical stimuli after neurological injuries

The main objective of this study is to create and validate subject-specific models of the human neuromuscular system capable of estimating neuro-mechanical activity in vivo in healthy, post-stroke and SCI individuals. In addition, we want to prove…