62 results
This proof-of-principle evaluation aims to investigate whether a home-based balance training using an exergame (HEROES), following a single session of perturbation-based training improves reactive step quality in people with chronic stroke.
The primary objective is the evaluation of the potential positive effect of a compensatory memory strategy game on effective coping with memory problems and reducing subjective memory failures in ABI patients with memory deficits in the chronic…
The BeyeOMARKER study*s primary aim is to (1) evaluate the real-world predictive value of blood- and eye-based biomarkers for detection of AD-related clinical progression and biological changes in eye clinics. Secondly, we aim (2) to assess the…
The current study aims to obtain a better understanding of glymphatic dysfunction in dementia of the Alzheimer*s type and its preclinical stages.The main objective of this study is to improve our understanding of the potential link between…
The precise pathophysiology for hypertension causing brain damage is still unclear, although microvascular dysfunction is thought to play an important role. Therefore, in this study the small cerebral vessels will be studied in more detail. The main…
The main objective is to quantify neuroinflammation using [11C]SMW139 PET-scans in subjects along the AD continuum and age/sex-matched cognitively unimpaired subjects.
The main objective is to quantify neuroinflammation using [11C]SMW139 PET-scans in subjects along the AD continuum and age/sex-matched cognitively unimpaired subjects.
We aim to develop an innovative personalized prognostic model for outcome of children with TBI, using a unique combination of demographic, pre-injury and clinical predictors. The value of innovative MRI techniques and promising machine learning…
To evaluate the effects of LCZ696 compared to valsartan on cognitive function over 3 years in patients with HFpEF as assessed by the CogState cognitive assessment battery.
Primary Objective: - To investigate whether or not persistent complaints and poor outcome after mTBI be explained by an interaction between physiological and psychological factors.Secondary Objective(s): - To identify specific patterns of brain…
The objective is to describe differences in MRI patterns in presymptomatic mutation carriers, patients with mild dementia and controls. We will study whether these patterns are specific depending on the type of dementia (FTD/AD) or mutation (GRN/…
The aim of the current study is to determine whether a *liberal* strategy of maintaining Hb concentrations above 9 g/dL would result in a different neurological outcome when compared to a *restrictive* approach to red-cell transfusion to avoid…
This proof-of-concept study aims to non-invasively detect amyloid-beta (Aβ)-plaques in the retina of AD patients using a Heidelberg Spectralis scanner with Curcumin as labeling fluorophore. The retinal Aβ-plaques will be related to currently used AD…
To determine the difference in change over time of cognitive function and brain magnetic resonance imaging (MRI) measurements between breast cancer survivors and cancer-free individuals.
The present study examines stroke patients* language abilities as well as the recruitment of additional brain areas in language use over time to compensate for stroke-induced language deficits.
To improve aftercare for patients with ABI receiving outpatient rehabilitation, aimed at promoting an active lifestyle to prevent persistent complaints after ABI and poor HR-QoL.
Our objective is to get insight into whether and how the visual system reorganises after acquiring HH. Visual processing will be investigated and cortical reorganisation at a structural level will be examined. For this purpose, we will assess…
The aim of this study is to identify structural constraints to right-hemisphere reorganisation. It is hypothesised that reorganisation of language function to the right hemisphere is largely dependent on the integrity of the corpus callosum fibres…
This study aims to investigate the retina, macula and optic nerve head with Optical Coherence Tomography (OCT) in a cohort of AD patients in order to identify a neurodegenerative signature of AD consisting of neuroretinal degeneration, vascular…
The hypothesis is that individual music therapy intervention, according to professional standards, will lead to more symptom reduction of BPSD and a better quality of life based on parameters observed by care givers, compared with listening to music…