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Determination of risk factors for developing osteoporosis in COPD GOLD II patients. A case control study to identify possible risk factors for developing osteoporosis in COPD GOLD II patients.

Determination of possible risk factors for developing osteoporosis in GOLD II COPD patients.

Action Plan to enhance self-management and early detection of exacerbations in patients with COPD; a Randomized Controlled Trial

Primary Objective: To evaluate the effectiveness of an individualized AP (initiating early detection of exacerbations and prompt intervention) on recovery of symptom-based Quality of life in the event of an exacerbation. Secondary Objective(s): To…

Study to investigate the relationship between AGE reader value, COPD and smoking history.

To investigate the association between AGE, COPD severity and number of packyears.

A MULTINATIONAL, MULTICENTRE, RANDOMISED, OPEN-LABEL, ACTIVE-CONTROLLED, 26-WEEK, 2-ARM, PARALLEL GROUP STUDY TO EVALUATE THE NON-INFERIORITY OF FIXED COMBINATION OF BECLOMETASONE DIPROPIONATE PLUS FORMOTEROL FUMARATE PLUS GLYCOPYRRONIUM BROMIDE ADMINISTERED VIA PMDI (CHF 5993) VERSUS FIXED COMBINATION OF FLUTICASONE FUROATE PLUS VILANTEROL ADMINISTERED VIA DPI (RELVAR*) PLUS TIOTROPIUM BROMIDE (SPIRIVA®) FOR THE TREATMENT OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE.

Primary objectives To demonstrate the non-inferiority of CHF 5993 pMDI versus fixed combination of fluticasone furoate/vilanterol plus tiotropium in terms of quality of life (change from baseline in the St. George*s Respiratory Questionnaire [SGRQ]…

The effectiveness of an Oscillating Positive Expiratory Pressure (OPEP) Therapy on respiratory symptoms in patients with COPD/chronic bronchitis with excess mucus in daily clinical practice

To evaluate the effect of OPEP use on respiratory symptoms in patients with COPD or chronic bronchitis with excess mucus in daily clinical practice.

Inhaler instruction in patients with asthma or COPD: can it be improved?

to investigate the additional value of the use of inhaler specific instruction cards in inhaler education in patients with asthma or COPD.

Does monitored discontinuation of inhaled corticosteroids (ICS) for primary care COPD patients without a clear indication for ICS according to current guidelines results in a reduction of ICS use without adverse health effects.

The objective of the study is to investigate whether discontinuation of inhaled corticosteroids (ICS) for patients without a clear indication for ICS according to current guidelines results in a reduction of ICS use without adverse health effects…

Determining the metabolic load of walking in water compared to walking on land (over-ground) in people with COPD, who are normal weight or obese, compared to peak exercise metabolic response: a randomized cross-over pilot trial

The aim of this study is to evaluate the metabolic load during a single session of moderate intensity walking in water compared to walking on land (over-ground) in people with COPD who are normal weight and obese, compared with peak exercise…

A novel monitoring system for continuous 24/7 monitoring of patients with COPD

Present and evaluate a novel monitoring system for 24/7 continuously monitoring of COPD patients, using cHealth technologies.

Pharmacogenetics of Asthma Medication in Children: Medication with Anti-inflammatory effects with special focus on Neutrophils.

The overall aim of the project is to define effects of genetic and non-genetic variants on pharmacological treatment response in children with asthma. The following questions will be answered:- What are the characteristics of children who do not…

An open label, randomised, parallel group clinical study to evaluate the effect of the Connected Inhaler System (CIS) on adherence to Relvar/Breo ELLIPTA therapy, in asthmatic subjects with poor control (study 207040)

Primary:To compare the effect of 6 months use of the CIS on adherence to ELLIPTA maintenance therapy when both the subject and the HCP are supplied with data from the maintenance sensor versus no data supplied to the subject and HCP (Arm 1 vs Arm 5…

Pulmonary RehabIlitation with Nasal-high-flow-support in COPD and Effectiveness: The PRINCE study

To determine the difference in increase in cycle endurance time after PR using NHF oxygen supplementation in patients during both exercise training and night time compared to patients using a conventional oxygen delivery systems.

Wearable technology to assess children*s asthma control in the home-situation

The objective is to find the most effective combination of wearable devices to accurately reflect paediatric asthma control in a home monitoring situation, by studying the relation of the home-measured signals to the currently used exercise…

A better understanding of molecular mechanisms leading to asthma and its remission.

Objective: to determine the underlying mechanisms and molecular events leading to remission of asthma.

High-altitude treatment versus treatment at sea level in patients with severe, refractory asthma:
a pragmatic randomized controlled trial

The primary objectives are twofold: 1) to compare the effect of 12 weeks of multidisciplinary pulmonary rehabilitation in a high-altitude centre with comparable rehabilitation in a sea level centre on asthma-specific quality of life (assessed with…

A Phase IV, 12-week, randomised, double-blind, triple dummy study to compare single inhaler triple therapy, fluticasone furoate/umeclidinium/vilanterol (FF/UMEC/VI) with multiple inhaler therapy (budesonide/formoterol plus tiotropium) based on lung function and symptoms in participants with chronic obstructive pulmonary disease

Primary:To evaluate the effects of singleinhaler triple therapy (FF/UMEC/VI)compared to multiple inhaler triplecombination therapy withbudesonide/formoterol plus tiotropiumafter 12 weeks of treatment on lungfunctionOther:To evaluate the effects of…

Health effects due to inhalation of ultrafine particles in healthy volunteers. Multiple short-term exposures to UFP near Schiphol Airport.
A cross-over study

We hypothesize that the toxic potency of UFP from air traffic is comparable to road traffic after inhalation by healthy humans. Therefore, we aim to:* Identify acute effects of short-term inhalation of ultrafine particles right next to Amsterdam…

The acute physiological effects of short-term roadside traffic exposure in patients with COPD

- To assess the feasibility of a study protocol to determine acute effects of short-term roadside traffic exposure (i.e. BC) in patients with COPD. - To collect preliminary data that provide insight in acute effects of short-term roadside traffic…

A 24-week treatment, multi-center, randomized, double-blind, double-dummy, parallel group study to compare Umeclidinium/Vilanterol, Umeclidinium, and Salmeterol in subjects with chronic obstructive pulmonary disease (COPD)

Primary:To compare the effect of UMEC/VI (62.5/25 mcg once daily) with UMEC (62.5 mcg once daily) on lung functionSecondary:To compare UMEC/VI, UMEC with salmeterol (50 mcg twice daily) on patient reported outcomes and on other COPD efficacy…

A Phase III, randomized, double-blind, active controlled, parallel group study, comparing the efficacy, safety and tolerability of the fixed dose combination FF/UMEC/VI with the fixed dose dual combination of FF/VI, administered once-daily via a dry powder inhaler in subjects with inadequately controlled asthma (study 205715)

Primary:To evaluate the effects of FF/UMEC/VI on lung function compared with FF/VI after 24 weeks of treatmentSecondary:To assess the efficacy (exacerbations), FEV1 3h post dose, asthma symptoms, safety and tolerability.