34 results
Primary Objective• To compare the anti-tumor efficacy of oral single-agent rociletinib, as measured by investigator assessment of the progression-free survival (PFS), with that of single-agent cytotoxic chemotherapy in patients with EGFR mutated,…
The main objective of the trial will be to assess safety and tolerability of combined treatmentwith nintedanib and pirfenidone.A secondary objective is to assess the exposure based on PK trough concentration values tonintedanib either given alone or…
1). To compare temporal fluctuations of lung function and inflammatory biomarkers in blood, nasal lavage, exhaled air and urine between patients with asthma and controls.2). To investigate the change in variations of these biomarkers upon…
With the aim to restrict inappropriate FFP transfusions to critically ill patients, a randomized clinical trial will be conducted in a subgoup of ICU patients undergoing an invasive procedure. The objective is to assess the effectiveness and costs…
We postulate that exhaled molecular profiling obtained from *breathprints* by electronic nose:1. Will discriminate eosinophilic asthma from non-eosinophilic asthma2. Is associated with individual biomarkers and specific proteomic profiles in induced…
Our hypothesis is that antibodies of COPD patients contribute to inflammatory processes leading to cell death, and that the level of cytotoxicity differs between COPD patients and healthy volunteers. The prime aim is to detect differences in…
Compare induction of anaesthesia using etomidate versus ketanest on hemodynamics, as well as microcirculatory consequences in patients admitted to the ICU and in need of ventilatory support.
Part I of the study: I) to determine if one or a batch of aging marker(s) is/are associated with the presence of objectively diagnosed COPD related co-morbidity (muscle wasting, osteoporosis, cardiovascular risk, glucose intolerance, renal failure,…
The objective of this study is to obtain information regarding the effectiveness and safety of a product called Foster® for the treatment of asthma. This product is a combination between two well known drugs: formoterol fumarate and beclomethasone…
The objective of this study is to test our hypothesis:Hypothesis - We postulate that the development of asthma in preschool children can be captured during the first 2 years of life by a minimally invasive *fingerprint* based on the combination of:…
Primary Objective: 1) To investigate if the intestinal permeability acutely increases during physical activity (submaximal cycle ergometry or ADL test) in clinically stable patients with moderate to severe COPD; 2) To investigate if the intestinal…
Besides more basic research into which RNA-binding proteins and microRNAs regulate the expression of inflammatory mediators in airway epithelial cells, we will also assess these proteins and microRNAs in airway epithelial cells from patients with…
To investigate whether cough measurements by means of VAS (0-100 points) after 6 months (+/- 6 points) in patients with chronic cough who are diagnosed and treated by a nurse practitioner outpatient clinic are equal to an outpatient clinic leaded by…
Primary endpoint:Measuring lymphocyte response in patients with suspected pulmonary bird fanciers lung by ELISPOT technique.
To investigate whether exposure to nanoparticles is able to induce short-term functional changes in the brain, we previously exposed human volunteers for one hour to diesel exhaust particulates (300 ug/m3) and followed their brain activity during…
We hypothesize that expiratory VOC-analysis by electronic nose is capable of:1. Discriminating between asymptomatic infants and infants with respiratory wheeze.2. Discriminating between parent-reported and doctors-confirmed wheezy infants.The aim of…
which particles can be found in induced sputum of construction workers? What is the composition, size and concentration of quartz particles measured in sputum of the different exposure groups?
To compare the outcomes of stereotactic radiotherapy (experimental arm) with that following primary surgery (standard arm) in a prospective phase III trial.
Research questions:Is the chronic inflammatory response in COPD caused by a dysfunction of regulatory T cells?1. Is the number of Tregs decreased in COPD?2. Is the function of the Tregs impaired in COPD? And if so,a. Is this associated with a…
Objective: To determine whether serum concentration guided dosing of infliximab is not inferior to standard dosing based on bodyweight in patients with severe sarcoidosis in terms of FVC change at 26 weeks.